Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density

Koay, MA, Duncan, EL, Ralston, SH, Compston, JE, Cooper, C, Keen, R, Langdahl, BL, MacLelland, A, O'Riordan, J, Pols, HA, Reid, DM, Uitterlinden, AG, Wass, AH and Brown, MA (2004) Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density. Journal of Bone And Mineral Research, 19 10: 1619-1627. doi:10.1359/JBMR.040704


Author Koay, MA
Duncan, EL
Ralston, SH
Compston, JE
Cooper, C
Keen, R
Langdahl, BL
MacLelland, A
O'Riordan, J
Pols, HA
Reid, DM
Uitterlinden, AG
Wass, AH
Brown, MA
Title Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density
Journal name Journal of Bone And Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1359/JBMR.040704
Open Access Status DOI
Volume 19
Issue 10
Start page 1619
End page 1627
Total pages 9
Place of publication Malden, MA United States
Publisher Wiley-Blackwell Publishing, Inc.
Language eng
Abstract Understanding the influence of environmental factors on population dynamics is fundamental to many areas in biology. Survival is a key factor of population biology, as it is thought to be the predominant driver of growth in long-lived passerines, which can be influenced by both biotic and abiotic environmental conditions. We used mark-recapture methods and generalized linear mixed models to test the influence of density and climatic variation, measured at a regional and local scale (Southern Oscillation Index [SOI] and rainfall, respectively), on seasonal variation in survival rates of an insular population of Silvereyes (Zosterops lateralis chlorocephalus), during a 15-year study period, off the east coast of Australia. We found overall high survival rates for adults and juveniles (81% and 59%, respectively). Local scale climate (i.e. rainfall) and density were the principal environmental factors influencing their survival, both with a negative relationship. A significant interactive effect of density and rainfall influenced survival as they both increased. However, survival remained low when density was at it highest, independent of the amount of rainfall. Nestling survival was negatively influenced by rainfall and density, positively by SOI, and chicks that hatched later in the breeding season had higher survival rates. The regional scale climate variable (i.e. SOI) did not explain survival rates as strongly as rainfall in any age class. Our results contribute to the understanding of insular avian population dynamics and the differential effects of environmental factors across age classes. Climatic predictions expect El Niño events to increase, meaning dryer conditions in eastern Australia, potentially increasing Silvereye survival across age classes. However, the long-term effect of lower rainfall on food availability is unknown; consequently, the outcome of lower rainfall on Silvereye survival rates is uncertain.
Formatted abstract
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.
Keyword Endocrinology and Metabolism
Osteoporosis
Single nucleotide polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 17 Oct 2007, 22:53:25 EST