BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation

Logarajah, S, Hunter, P, Kraman, M, Steele, D, Lakhani, S, Bobrow, L, Venkitaraman, A and Wagner, S (2003) BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation. Oncogene, 22 36: 5572-5578. doi:10.1038/sj.onc.1206689


Author Logarajah, S
Hunter, P
Kraman, M
Steele, D
Lakhani, S
Bobrow, L
Venkitaraman, A
Wagner, S
Title BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1038/sj.onc.1206689
Open Access Status DOI
Volume 22
Issue 36
Start page 5572
End page 5578
Total pages 7
Place of publication London
Publisher Nature Publishing Group
Language eng
Abstract Appropriately timed proliferation, differentiation and apoptosis are essential to the normal functions of the mammary epithelium. Here, we report that the transcription factor BCL-6 is expressed in mammary epithelium in nonpregnant animals as well as during early pregnancy. When overexpressed in the nontransformed EpH4 mammary epithelial cell line, BCL-6 prevents the STAT-driven expression of the milk protein beta-casein and duct formation, and prevents apoptosis. Consistent with an antiapoptotic function, we demonstrate that BCL-6 is expressed in 68% of histologically high-grade ductal breast carcinomas, which are clinically the most aggressive. BCL-6 has previously been characterized as a regulator of B lymphocyte growth and development, but our work identifies a novel role for it in mammary epithelial differentiation, which may also implicate it in carcinogenesis.
Keyword Biochemistry & Molecular Biology
Oncology
Cell Biology
Genetics & Heredity
mammary epithelium
differentiation
breast cancer
BCL-6
STAT
Germinal-center Formation
Transcriptional Repressor
Terminal Differentiation
Alpha-6-beta-4 Integrin
Gene
Protein
Inflammation
Phosphorylation
Morphogenesis
Suppression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Oct 2007, 22:14:01 EST