Cholecystokinin-like immunoreactive amacrine cells in the rat retina

Firth, SI, Varela, C, De la Villa, P and Marshak, DW (2002) Cholecystokinin-like immunoreactive amacrine cells in the rat retina. Visual Neuroscience, 19 4: 531-540. doi:10.1017/S0952523802194156

Author Firth, SI
Varela, C
De la Villa, P
Marshak, DW
Title Cholecystokinin-like immunoreactive amacrine cells in the rat retina
Journal name Visual Neuroscience   Check publisher's open access policy
ISSN 0952-5238
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1017/S0952523802194156
Open Access Status DOI
Volume 19
Issue 4
Start page 531
End page 540
Total pages 10
Place of publication New York
Publisher Cambridge Univ Press
Language eng
Abstract High levels of endogenous cholecystokinin (CCK) are present in the rat retina (Eskay & Beinfeld, 1982), but the cellular localization and physiological actions of CCK in the rat retina are uncertain. The goals of this study were to characterize the cells containing CCK, identify cell types that interact with CCK cells, and investigate the effects of CCK on rod bipolar cells. Rat retinas were labeled with antibody to gastrin-CCK (gCCK) using standard immunofluorescence techniques. Patch-clamp methods were used to record from dissociated rod bipolar cells from rats and mice. Gastrin-CCK immunoreactive (-IR) axons were evenly distributed throughout the retina in stratum 5 of the inner plexiform layer of the rat retina. However, the gCCK-IR somata were only detected in the ganglion cell layer in the peripheral retina. The gCCK-IR cells contained glutamate decarboxylase,and some of them also contained immunoreactive substance P. Labeled axons contacted PKC-IR rod bipolar cells, and recoverin-IR ON-cone bipolar cells. CCK-octapeptide inhibits GABA(C) but not GABA(A) mediated currents in dissociated rod bipolar cells.
Keyword Neurosciences
GABA(C) receptors
substance P
bipolar cells
displaced amacrine cells
Cone Bipolar Cells
Inner Plexiform Layer
Rabbit Retina
Synaptic Connections
Interplexiform Cells
Gaba(c) Receptors
Mammalian Retina
Calcium Current
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Oct 2007, 21:43:00 EST