Mixed germ cell tumor in the eye of a dog

Patterson-Kane, JC, Schulman, FY, Santiago, N, McKinney, L and Davis, CJ (2001) Mixed germ cell tumor in the eye of a dog. Veterinary Pathology, 38 6: 712-714. doi:10.1354/vp.38-6-712

Author Patterson-Kane, JC
Schulman, FY
Santiago, N
McKinney, L
Davis, CJ
Title Mixed germ cell tumor in the eye of a dog
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1354/vp.38-6-712
Open Access Status Not Open Access
Volume 38
Issue 6
Start page 712
End page 714
Total pages 3
Place of publication Lawrence
Publisher Amer Coll Vet Pathologist
Language eng
Abstract A 3-year-old female neutered Staffordshire Bull Terrier presented with a mixed germ. cell tumor involving the base of the iris and the ciliary body of the right eye. The tumor mass was composed primarily of packeted vacuolated, polygonal (hepatoid) cells and small round cells; epithelial cells lining tubuloacinar structures were a less prominent component. The hepatoid and round cells stained positively for alpha-fetoprotein and cytokeratin. The epithelial cells stained positively for cytokeratin only, and some contained cytoplasmic mucin droplets. The polygonal cells were interpreted as a hepatoid variant of yolk sac tumor, and the epithelial cells were considered a teratomatous component. Trabeculae of bone were observed within the mass and may have been metaplastic or a teratomatous element. Extragonadal germ cell tumors are rare in dogs and have previously been reported only in the suprasellar region. This is the first report of this tumor type in the eye of a nonhuman species.
Keyword Pathology
Veterinary Sciences
extragonadal germ cell tumor
eye immunohistochemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Wed, 17 Oct 2007, 21:06:03 EST