Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings

Lewis, Richard J., Molgo, Jordi and Adams, David J. (2000). Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings. In Luis M. Botana (Ed.), Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection 1st ed. (pp. 419-447) New York: Marcel Dekker Inc..

Author Lewis, Richard J.
Molgo, Jordi
Adams, David J.
Title of chapter Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings
Title of book Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection
Place of Publication New York
Publisher Marcel Dekker Inc.
Publication Year 2000
Edition 1st
ISBN 0824789563
Editor Luis M. Botana
Chapter number 20
Start page 419
End page 447
Total pages 29
Total chapters 35
Collection year 2000
Language eng
Subjects 320500 Pharmacology and Pharmaceutical Sciences
Abstract/Summary The increased harvesting of tropical marine resources has contributed to an increased incidence of human intoxication associated with fish consumption. Of these fish poisonings, ciguatera is arguably the most significant, both in terms of the number and the severity of poisoning episodes. The disease is associated with the consumption of many species of tropical and subtropical fishes from the Indo-Pacific Oceans and Caribbean Sea that have become contaminated by ciguatoxins which arise from blooms of certain strains of the benthic dinoflagellate Gambierdiscus toxicus. Environmental degradation may play a role in the increased incidence of ciguatera, although the precise factors involved remain elusive. The role played by other marine toxins in ciguatera, including other toxins produced by benthic dinoflagellates, has not been demonstrated, although mild cases of palytoxin poisoning may be mistaken for ciguatera. Over the last decade there have been rapid advances in our knowledge of the precise chemical and pharmacological properties of the toxins which contribute to the different forms of fish poisoning, especially those toxins involved in ciguatera. Ciguatera can be defined as an illness caused by the consumption of polyether sodium channel activator toxins (ciguatoxins, CTXs) that accumulate to levels that cause acute human intoxication characterized by neurological, gastrointestinal, and cardiovascular disorders. The ciguatoxins are a family of lipid-soluble, highly oxygenated, cyclic polyether molecules.
Keyword ciguatera
fish consumption
ciguatoxicity
ciguatoxins
benthic dinoflagellates
Gambierdiscus toxicus

Document type: Book Chapter
Collection: Queensland Brain Institute Publications
 
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Created: Thu, 27 Sep 2007, 14:56:17 EST by Thelma Whitbourne on behalf of Queensland Brain Institute