The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans

Loftus, B. J., Fung, E., Roncaglia, P., Rowley, D., Amedeo, P., Bruno, D., Vamathevan, J., Miranda, M., Anderson, I. J., Fraser, J. A., Allen, J. E., Bosdet, I. E., Brent, M. R., Chiu, R., Doering, T. L., Dontin, M. J., D'Souza, C. A., Fox, D. S., Grinberg, V., Fu, J. M., Fukushima, M., Haas, B. J., Huang, J. C., Janbon, G., Jones, S. J. M., Koo, H. L., Krzywinski, M. I., Kwon-Chung, J. K., Lengeler, K. B. and Maiti, R. (2005) The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science, 307 5713: 1321-1324. doi:10.1126/science.1103773

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Author Loftus, B. J.
Fung, E.
Roncaglia, P.
Rowley, D.
Amedeo, P.
Bruno, D.
Vamathevan, J.
Miranda, M.
Anderson, I. J.
Fraser, J. A.
Allen, J. E.
Bosdet, I. E.
Brent, M. R.
Chiu, R.
Doering, T. L.
Dontin, M. J.
D'Souza, C. A.
Fox, D. S.
Grinberg, V.
Fu, J. M.
Fukushima, M.
Haas, B. J.
Huang, J. C.
Janbon, G.
Jones, S. J. M.
Koo, H. L.
Krzywinski, M. I.
Kwon-Chung, J. K.
Lengeler, K. B.
Maiti, R.
Title The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2005-02-25
Year available 2005
Sub-type Article (original research)
DOI 10.1126/science.1103773
Open Access Status DOI
Volume 307
Issue 5713
Start page 1321
End page 1324
Total pages 4
Place of publication Washington
Publisher American Association for the Advancement of Science
Language eng
Subject 270202 Genome Structure
270000 Biological Sciences
Abstract Cryptococcus neoformans is a basidionnycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its similar to20-megabase genome, which contains similar to6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.
Keyword Multidisciplinary Sciences
Q-Index Code C1
Grant ID R01 HL088905
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 424 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 20 Sep 2007, 05:02:53 EST