Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis

Zhang, J. Y., Chen, Y. B., Hardwick, J. M., Miller, M. I., Plachez, C., Richards, L. J., Yarowsky, P., van Zijl, P. and Mori, S. (2005) Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis. Journal of Neuroscience, 25 8: 1881-1888. doi:10.1523/JNEUROSCI.4129-04.2005

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Author Zhang, J. Y.
Chen, Y. B.
Hardwick, J. M.
Miller, M. I.
Plachez, C.
Richards, L. J.
Yarowsky, P.
van Zijl, P.
Mori, S.
Title Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2005-01-01
Year available 2005
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4129-04.2005
Open Access Status File (Publisher version)
Volume 25
Issue 8
Start page 1881
End page 1888
Total pages 8
Place of publication Washington
Publisher Soc Neuroscience
Language eng
Abstract A new technique based on diffusion tensor imaging and computational neuroanatomy was developed to efficiently and quantitatively characterize the three- dimensional morphology of the developing brains. The technique was used to analyze the phenotype of conditional Bcl-x knock-out mice, in which the bcl-x gene was deleted specifically in neurons of the cerebral cortex and hippocampus beginning at embryonic day 13.5 as cells became postmitotic. Affected brain regions and associated axonal tracts showed severe atrophy in adult Bcl-x-deficient mice. Longitudinal studies revealed that these phenotypes are established by regressive processes that occur primarily during the first postnatal week, whereas neurogenesis and migration showed no obvious abnormality during embryonic stages. Specific families of white matter tracts that once formed normally during the embryonic stages underwent dramatic degeneration postnatally. Thus, this technique serves as a powerful tool to efficiently localize temporal and spatial manifestation of morphological phenotype.
Keyword Neurosciences
magnetic
resonance
diffusion
cortex
axon
development
phenotype
Anisotropic Water Diffusion
Developing Mouse-brain
Nervous-system
Anatomy
Tissues
Echo
Mice
Mri
Q-Index Code C1
Grant ID P41 RR15241-01
R01 AG20012-01
P41 EB015909
R03 HD41407-01A1
R01 NS37402
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Thu, 20 Sep 2007, 03:10:48 EST