The transcription factor gene Nfib is essential for both lung maturation and brain development

Steele-Perkins, George, Plachez, Céline, Butz, Kenneth G., Yang, Guanhu, Bachurski, Cindy J., Kinsman, Stephen L., Litwack, E. David, Richards, Linda J. and Gronostajski, Richard M. (2005) The transcription factor gene Nfib is essential for both lung maturation and brain development. Molecular and Cellular Biology, 25 2: 685-698. doi:10.1128/MCB.25.2.685-698.2005

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Author Steele-Perkins, George
Plachez, Céline
Butz, Kenneth G.
Yang, Guanhu
Bachurski, Cindy J.
Kinsman, Stephen L.
Litwack, E. David
Richards, Linda J.
Gronostajski, Richard M.
Title The transcription factor gene Nfib is essential for both lung maturation and brain development
Journal name Molecular and Cellular Biology   Check publisher's open access policy
ISSN 0270-7306
Publication date 2005-01-01
Year available 2005
Sub-type Article (original research)
DOI 10.1128/MCB.25.2.685-698.2005
Open Access Status File (Publisher version)
Volume 25
Issue 2
Start page 685
End page 698
Total pages 14
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract The phylogenetically conserved nuclear factor I (NFI) gene family encodes site-specific transcription factors essential for the development of a number of organ systems. We showed previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defects, whereas Nfic-deficient mice have a genesis of molar tooth roots and severe incisor defects. Here we show that Nfib-deficient mice possess unique defects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but more severe than, those seen in Nfia-deficient animals. In addition, loss of Nfib results in defects in basilar ports formation aud hippocampus development that are not seen in Nfia-deficient mice. Heterozygous Nfib-deficient animals also exhibit callosal agenesis and delayed lung maturation, indicating haploinsufficiency at the Nfib locus. The similarity in brain defects in Nfia- and Nfib-deficient animals suggests that these two genes may cooperate in late fetal forebrain development, while Nfib is essential for late fetal lung maturation and development of the pons.
Keyword Biochemistry & Molecular Biology
Cell Biology
Adenovirus Dna-replication
Surfactant Protein-c
Dentate Gyrus
Expression Patterns
Deficient Mice
Mouse Strains
Granule Cells
Axon Guidance
Q-Index Code C1
Grant ID HL60907
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 163 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 20 Sep 2007, 04:01:25 EST