Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human

Richards, L. J., Plachez, C. and Ren, T. (2004) Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human. Clinical Genetics, 66 4: 276-289. doi:10.1111/j.1399-0004.2004.00354.x


Author Richards, L. J.
Plachez, C.
Ren, T.
Title Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human
Journal name Clinical Genetics   Check publisher's open access policy
ISSN 0009-9163
Publication date 2004-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1399-0004.2004.00354.x
Volume 66
Issue 4
Start page 276
End page 289
Total pages 14
Place of publication Copenhagen
Publisher Blackwell Munksgaard
Language eng
Abstract The development of the corpus callosum depends on a large number of different cellular and molecular mechanisms. These include the formation of midline glial populations, and the expression of specific molecules required to guide callosal axons as they cross the midline. An additional mechanism used by callosal axons from neurons in the neocortex is to grow within the pathway formed by pioneering axons derived from neurons in the cingulate cortex. Data in humans and in mice suggest the possibility that different mechanisms may regulate the development of the corpus callosum across its rostrocaudal and dorsoventral axes. The complex developmental processes required for formation of the corpus callosum may provide some insight into why such a large number of human congenital syndromes are associated with agenesis of this structure.
Keyword Genetics & Heredity
axon guidance
cingulate cortex
commissure formation
genetic regulation
glia
Npn1
Robo
slitz
Rubinstein-taybi-syndrome
X-linked Hydrocephalus
Central-nervous-system
Reduced Hippocampal Commissure
Multiple Congenital-anomalies
Autosomal Recessive Syndrome
Abnormal Brain-development
Amyloid-precursor Protein
Wolf-hirschhorn-syndrome
Spastic Paraplegia Spg1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 129 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 142 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 20 Sep 2007, 04:02:33 EST