The glial sling is a migratory population of developing neurons

Shu, T. Z., Li, Y., Keller, A. and Richards, L. J. (2003) The glial sling is a migratory population of developing neurons. Development, 130 13: 2929-2937. doi:10.1242/dev.00514

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Author Shu, T. Z.
Li, Y.
Keller, A.
Richards, L. J.
Title The glial sling is a migratory population of developing neurons
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 2003-01-01
Year available 2003
Sub-type Article (original research)
DOI 10.1242/dev.00514
Open Access Status File (Publisher version)
Volume 130
Issue 13
Start page 2929
End page 2937
Total pages 9
Place of publication Cambridge
Publisher Company of Biologists Ltd
Language eng
Abstract For two decades the glial sling has been hypothesized to act as a guidance substratum for developing callosal axons. However, neither the cellular nature of the sling nor its guidance properties have ever been clearly identified. Although originally thought to be glioblasts, we show here that the subventricular zone cells forming the sling are in fact neurons. Sling cells label with a number of neuronal markers and display electrophysiological properties characteristic of neurons and not glia. Furthermore, sling cells are continuously generated until early postnatal stages and do not appear to undergo widespread cell death. These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance.
Keyword Developmental Biology
midline glia
glial sling
glial wedge
corpus callosum
axon guidance
cell migration
cortical development
Subplate Neurons
Thalamocortical Connections
Anterior Commissure
Pyramidal Neurons
Growth Cones
Cavum Septi
Axon Tracts
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NS31078
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 47 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 55 times in Scopus Article | Citations
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Created: Thu, 20 Sep 2007, 04:11:18 EST