Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum

Richards, L. J. (2002) Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum. Brazilian Journal of Medical And Biological Research, 35 12: 1431-1439. doi:10.1590/S0100-879X2002001200004

Author Richards, L. J.
Title Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum
Journal name Brazilian Journal of Medical And Biological Research   Check publisher's open access policy
ISSN 0100-879X
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1590/S0100-879X2002001200004
Open Access Status DOI
Volume 35
Issue 12
Start page 1431
End page 1439
Total pages 9
Place of publication Sao Paulo
Publisher Assoc Bras Divulg Cientifica
Language eng
Abstract The corpus callosum is a large fiber tract that connects neurons in the right and left cerebral hemispheres. Agenesis of the corpus callosum (ACC) is associated with a large number of human syndromes but little is known about why ACC occurs. In most cases of ACC, callosal axons are able to grow toward the midline but are unable to cross it, continuing to grow into large swirls of axons known as Probst bundles. This phenotype suggests that in some cases ACC may be due to defects in axonal guidance at the midline. General guidance mechanisms that influence the development of axons include chemoattraction and chemorepulsion, presented by either membrane-bound or diffusible molecules. These molecules are not only expressed by the final target but by intermediate targets along the pathway, and by pioneering axons that act as guides for later arriving axons. Midline glial populations are important intermediate targets for commissural axons in the spinal cord and brain, including the corpus callosum. The role of midline glial populations and pioneering axons in the formation of the corpus callosum are discussed. Finally the differential guidance of the ipsilaterally projecting perforating pathway and the contralaterally projecting corpus callosum is addressed. Development of the corpus callosum involves the coordination of a number of different guidance mechanisms and the probable involvement of a large number of molecules.
Keyword Biology
Medicine, Research & Experimental
midline glia
glial wedge
glial sling
indusium griseum glia
perforating pathway
corpus callosum
Abnormal Brain-development
Amyloid-precursor Protein
Growth Cones
Transgenic Mice
Anterior Commissure
Perinatal Lethality
Indusium Griseum
Subplate Neurons
Cingulate Cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Created: Thu, 20 Sep 2007, 01:06:55 EST