Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects

Pender, Michael P., Csurhes, Peter A., Greer, Judith M., Mowat, Paul D., Henderson, Robert D., Cameron, Kaye D., Purdie, David M., McCombe, Pamela A. and Good, Michael F. (2000) Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects. Journal of Immunology, 165 9: 5322-5331.

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Author Pender, Michael P.
Csurhes, Peter A.
Greer, Judith M.
Mowat, Paul D.
Henderson, Robert D.
Cameron, Kaye D.
Purdie, David M.
McCombe, Pamela A.
Good, Michael F.
Title Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2000-01-01
Year available 2000
Sub-type Article (original research)
Open Access Status File (Author Post-print)
Volume 165
Issue 9
Start page 5322
End page 5331
Total pages 10
Editor Fitch, F. W.
Hogan, M. M.
Place of publication Bethesada, MD
Publisher American Association of Immunologists
Language eng
Subject 320200 Immunology
320702 Central Nervous System
C1
321013 Neurology and Neuromuscular Diseases
730104 Nervous system and disorders
Abstract We have previously shown that patients with multiple sclerosis (MS) have increased T cell responses to the immunodominant region (residues 184-209) of myelin proteolipid protein (PLP). The present study investigated whether this reactivity fluctuates over time and correlates with disease activity. We performed monthly limiting dilution assays for 12-16 mo in four healthy subjects and five patients with relapsing-remitting MS to quantify the frequencies of circulating T cells proliferating in response to PLP41-58, PLP184-199, PLP190-209, myelin basic protein (MBP), MBP82-100, and tetanus toxoid. Disease activity was monitored by clinical assessment and gadolinium-enhanced magnetic resonance imaging of the brain. There were fluctuations in the frequencies of autoreactive T cells in all subjects. Compared with healthy controls, MS patients had significantly more frequent surges of T cells reactive to the 184-209 region of PLP, but infrequent surges of T cell reactivity to MBP82-100. There was temporal clustering of the surges of T cell reactivity to MBP82-100 and MBP, suggesting T cell activation by environmental stimuli. Some clinical relapses were preceded by surges of T cell reactivity to PLP184-209, and in one patient there was significant correlation between the frequency of T cells reactive to PLP184-199 and the total number of gadolinium-enhancing magnetic resonance imaging lesions. However, other relapses were not associated with surges of T cell reactivity to the Ags tested. T cells reactive to PLP184-209 may contribute to the development of some of the CNS lesions in MS.
Keyword multiple sclerosis
MS
reactivity
T cells
myelin proteolipid protein
PLP
Q-Index Code C1
Institutional Status UQ
Additional Notes This is an author version of an article originally published as Michael P. Pender, Peter A. Csurhes, Judith M. Greer, Paul D. Mowat, Robert D. Henderson, Kaye D. Cameron, David M. Purdie, Pamela A. McCombe, and Michael F. Good, "Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis Than in Healthy Subjects", The Journal of Immunology, 2000, 165: 5322-5331, with permission from The American Association of Immunologists (http://www.aai.org/). Copyright 2000. The American Association of Immunologists, Inc.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 23 Jun 2004, 10:00:00 EST