The Proximal Peripheral Nervous System Is A Major Site Of Demyelination In Experimental Autoimmune Encephalomyelitis Induced In The Lewis Rat By A Myelin Basic Protein-Specific T Cell

Pender, M. P., Tabi, Zsuzsanna, Nguyen, K. B. and McCombe, Pamela A. (1995) The Proximal Peripheral Nervous System Is A Major Site Of Demyelination In Experimental Autoimmune Encephalomyelitis Induced In The Lewis Rat By A Myelin Basic Protein-Specific T Cell. Acta Neuropathologica, 89 6: 527-531. doi:10.1007/s004010050284

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Author Pender, M. P.
Tabi, Zsuzsanna
Nguyen, K. B.
McCombe, Pamela A.
Title The Proximal Peripheral Nervous System Is A Major Site Of Demyelination In Experimental Autoimmune Encephalomyelitis Induced In The Lewis Rat By A Myelin Basic Protein-Specific T Cell
Journal name Acta Neuropathologica   Check publisher's open access policy
ISSN 0001-6322
Publication date 1995-05-01
Year available 1995
Sub-type Article (original research)
DOI 10.1007/s004010050284
Open Access Status File (Author Post-print)
Volume 89
Issue 6
Start page 527
End page 531
Total pages 5
Place of publication NEW YORK
Publisher SPRINGER VERLAG
Language eng
Subject 320207 Autoimmunity
321013 Neurology and Neuromuscular Diseases
Abstract Experimental autoimmune encephalomyelitis (EAE) was induced in the Lewis rat by the passive transfer of a cytotoxic CD4 + T cell clone specific for the 72-89 peptide of guinea-pig myelin basic protein (MBP). Histological studies on rats with neurological signs showed that inflammation was present in the proximal peripheral nervous system (PNS), namely the spinal roots, as well as in the central nervous system (CNS). The main sites of demyelination were the spinal roots in the PNS, and the spinal cord root entry and exit zones in the CNS. The major involvement of the proximal PNS in autoimmune disease directed at MBP is in marked contrast to EAE induced by immunisation with myelin proteolipid protein, where the inflammation and demyelination are restricted to the CNS. These findings may have implications for the human inflammatory demyelinating diseases including multiple sclerosis, in which MBP is a putative target antigen.
Keyword experimental autoimmune encephalomyelitis
EAE
multiple sclerosis
myelin basic protein
polyradiculitis
T cell clone
experimental allergic encephalomyelitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This is an author version of an article originally published as Pender, M. P., et al., The Proximal Peripheral Nervous System Is A Major Site Of Demyelination In Experimental Autoimmune Encephalomyelitis Induced In The Lewis Rat By A Myelin Basic Protein-Specific T Cell Clone. Acta Neuropathol (Berl), 1995. 89(6) : 527-31 with permission of the publisher. doi: 10.1007/s004010050284 Copyright 1995 Springer-Verlag. All rights reserved. The original publication is available from www.springerlink.com

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 03 Aug 2004, 10:00:00 EST