Developmental Expression of Elements of Hepatic Cholesterol Metabolism In The Rat

Smith, J. L., Lear, S. R. and Erickson, S. K. (1995) Developmental Expression of Elements of Hepatic Cholesterol Metabolism In The Rat. Journal of Lipid Research, 36 4: 641-652.

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Author Smith, J. L.
Lear, S. R.
Erickson, S. K.
Title Developmental Expression of Elements of Hepatic Cholesterol Metabolism In The Rat
Journal name Journal of Lipid Research   Check publisher's open access policy
ISSN 0022-2275
Publication date 1995-04-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 36
Issue 4
Start page 641
End page 652
Total pages 12
Language eng
Subject 321006 Gastroenterology and Hepatology
Abstract The expression of several key enzymes and receptors of rat hepatic cholesterol metabolism was studied during development. Among major findings were: acyl coenzyme A:cholesterol acyltransferase, the cholesteryl ester hydrolases, cholesterol-7 alpha-hydroxylase and the alpha 2-macroglobulin receptor (LRP) were very low in fetal livers, but all were induced shortly before birth, suggesting that these elements are important for extrauterine life. Although the other elements continued to increase, by day 6 of postnatal life, cholesterol-7 alpha-hydroxylase had reached undetectable levels. It reappeared by day 12 of suckling, placing it in the group of late-appearing activities necessary for the fully mature hepatic phenotype. Changes in acyl coenzyme A:cholesterol acyltransferase activity appeared due predominantly to changes in amount of active protein. The cholesteryl ester hydrolase (CEH) activities all showed different developmental patterns, suggesting that each was a unique activity. The bile salt- dependent CEH activity was much higher in the suckling period than in the adult where it was almost undetectable, suggesting that this CEH may have its major importance in the suckling period of development. Low density lipoprotein receptors exhibited a pattern very different from that of the alpha 2-macroglobulin receptors and did not show consistent correlation with any other elements. At some developmental time points, the relationships amongst the elements differed significantly from the adult pattern. These studies provide for the first time an integrated picture of developmental expression of key elements of hepatic cholesterol metabolism and set the stage for further studies on their modes of regulation.
Keyword acyl coenzyme A:cholesterol acyltransferase
cholesteryl ester hydrolase
3-hydroxy-3-methylglutaryl coenzyme A reductase
low density lipoprotein receptor
alpha2-macroglobulin receptor (LRP)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This article is abstract only. The full text of the article can be downloaded from the JLR web site (

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 42 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 12 Nov 2004, 10:00:00 EST