Diastolic dysfunction is a manifestation of ventricular-vascular interaction in patients with type 2 diabetes mellitus

Sharman, James E., Haluska, Brian A., Fang, Zhi Y., Prins, Johannes B. and Marwick, Thomas H. (2005). Diastolic dysfunction is a manifestation of ventricular-vascular interaction in patients with type 2 diabetes mellitus. In: Franklin Rosenfeldt, Heart Lung & Circulation: Abstracts for the Cardiac Society of Australia and New Zealand Annual Scientific Meeting. Cardiac Society of Australia and New Zealand 53rd Scientific Meeting, Perth, Western Australia, (S101-S101). 9th - 12th August, 2005. doi:10.1016/j.hlc.2005.04.007


Author Sharman, James E.
Haluska, Brian A.
Fang, Zhi Y.
Prins, Johannes B.
Marwick, Thomas H.
Title of paper Diastolic dysfunction is a manifestation of ventricular-vascular interaction in patients with type 2 diabetes mellitus
Conference name Cardiac Society of Australia and New Zealand 53rd Scientific Meeting
Conference location Perth, Western Australia
Conference dates 9th - 12th August, 2005
Proceedings title Heart Lung & Circulation: Abstracts for the Cardiac Society of Australia and New Zealand Annual Scientific Meeting   Check publisher's open access policy
Place of Publication Australia
Publisher Elsevier Ltd
Publication Year 2005
DOI 10.1016/j.hlc.2005.04.007
Open Access Status Not Open Access
ISSN 1443-9506
1444-2892
Editor Franklin Rosenfeldt
Volume 14
Issue 1 (Supplement 1)
Start page S101
End page S101
Total pages 1
Language eng
Abstract/Summary Vascular disease is accelerated in patients with Type 2 diabetes mellitus (T2DM). Since the systemic vasculature plays a pivotal role in myocardial loading, this study aimed to determine the effect of arterial characteristics on left ventricular (LV) morphology and function in patients with T2DM. Conventional echocardiography and tissue Doppler imaging were performed in 172 T2DM patients (95 men; aged 55±11y) with preserved ejection fraction (62±5%). Patients were stratified into groups based on LV geometric pattern (normal [n = 79], concentric remodeling [n = 33], concentric hypertrophy [n = 29], eccentric hypertrophy [n = 31]). Total arterial compliance (TAC) was recorded by simultaneous radial tonometry and aortic outflow pulsed wave Doppler. Arterial (brachial and carotid) structure and function were determined by standard ultrasound methods. There were no significant differences between the LV geometric groups in demographic or clinical parameters. The concentric hypertrophy group had significantly increased carotid artery diameter (6.0±0.7mm versus 6.5±0.7mm; p < 0.05) and stiffness (1912±1203 dynes/cm2mm versus 2976±2695 dynes/cm2mm×10−6; p < 0.05) compared to those with normal geometry. However, TAC did not differ between groups. LV diastolic function, as determined by the ratio of diastolic mitral inflow velocity to mitral annulus tissue velocity (E/E_), was significantly associated with carotid artery relative wall thickness and intima media thickness (p < 0.05). Moreover, E/E_ was independently predicted by carotid artery relative wall thickness (β = 22.9; p = 0.007). We conclude that structural characteristics of the carotid artery are associated with abnormal LV structure and function in patients with T2DM. The LV functional irregularities may be a downstream consequence of amplified pressure wave reflections effecting sub-optimal ventricular-vascular interaction.
Subjects EX
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Q-Index Code EX

 
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Created: Fri, 24 Aug 2007, 06:25:30 EST