Cluster analysis of the p53 genetic regulatory network: topology and biology

Hallinan, Jennifer S. (2004). Cluster analysis of the p53 genetic regulatory network: topology and biology. In: G. Fogel, Proceedings of the 2004 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. IEEE 2004 Symposium on Computational Intelligence in Bioinforn, La Jolla, CA, USA, (1-8). 7-8 October 2004. doi:10.1109/CIBCB.2004.1393924


Author Hallinan, Jennifer S.
Title of paper Cluster analysis of the p53 genetic regulatory network: topology and biology
Conference name IEEE 2004 Symposium on Computational Intelligence in Bioinforn
Conference location La Jolla, CA, USA
Conference dates 7-8 October 2004
Proceedings title Proceedings of the 2004 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology
Journal name Proceedings of the 2004 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'04
Place of Publication Piscataway, NJ, USA
Publisher Institute of Electrical and Electronic Engineers
Publication Year 2004
Sub-type Fully published paper
DOI 10.1109/CIBCB.2004.1393924
Open Access Status
ISBN 0-7803-8728-7
Editor G. Fogel
Volume 1
Start page 1
End page 8
Total pages 8
Language eng
Abstract/Summary We describe a network module detection approach which combines a rapid and robust clustering algorithm with an objective measure of the coherence of the modules identified. The approach is applied to the network of genetic regulatory interactions surrounding the tumor suppressor gene p53. This algorithm identifies ten clusters in the p53 network, which are visually coherent and biologically plausible.
Subjects EX
280210 Simulation and Modelling
780105 Biological sciences
Q-Index Code EX

Document type: Conference Paper
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Fri, 24 Aug 2007, 06:19:18 EST