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Buscemi, Giacomo, Perego, Paola, Carenini, Nives, Nakanishi, Makoto, Chessa, Luciana, Chen, Junjie, Khanna, Kum Kum and Delia, Domenico (2004) Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene, 23 46: 7691-7700. doi:10.1038/sj.onc.1207986     71 Cited 73 times in Scopus73 0
Hinz, Michael, Stilmann, Michael, Arslan, Seda Çöl, Khanna, Kum Kum, Dittmar, Gunnar and Scheidereit, Claus (2010) A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular Cell, 40 1: 63-74. doi:10.1016/j.molcel.2010.09.008     140 Cited 140 times in Scopus140 6
Liu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014) A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 10: 6106-6127. doi:10.1093/nar/gku284     45 Cited 44 times in Scopus44 2
Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007) A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 20: 15248-15257. doi:10.1074/jbc.M700246200     34 Cited 34 times in Scopus34 0
Simpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011) Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 2: 153-165. doi:10.1016/j.humpath.2010.07.008   1 4 Cited 4 times in Scopus4 0
Lakhani, Sunil R., Khanna, Kum K. and Chenevix-Trench, Georgia (2010) Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?. Breast Cancer Research, 12 2: 104-1-104-2. doi:10.1186/bcr2483     3 Cited 4 times in Scopus4 0
Gatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001) Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 3: 289-294. doi:10.1038/sj.onc.1204111     50 Cited 62 times in Scopus62 0
Gatei, Magtouf, Sloper, Katie, Sorensen, Claus, Syljuasen, Randi, Falck, Jacob, Hobson, Karen, Savage, Kienan, Lukas, Jiri, Zhou, Bin-Bing, Bartek, Jiri and Khanna, Kum Kum (2003) Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278 17: 14806-14811. doi:10.1074/jbc.M210862200     214 Cited 221 times in Scopus221 0
Gatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001) Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 20: 17276-17280. doi:10.1074/jbc.M011681200     141 Cited 146 times in Scopus146 6
Khanna, K. K., Lavin, M. F., Jackson, S. P. and Mulhern, T. D. (2001) ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 11: 1052-1065. doi:10.1038/sj.cdd.4400874     148 Cited 168 times in Scopus168 0
Khanna, Kum Kum and Chenevix-Trench, Georgia (2004) ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility. Journal of Mammary Gland Biology and Neoplasia, 9 3: 247-262. doi:10.1023/B:JOMG.0000048772.92326.a1     25 Cited 25 times in Scopus25 3
Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015) ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 17: 8352-8367. doi:10.1093/nar/gkv754     11 Cited 11 times in Scopus11 1
Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 1: 115-119.     375
Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011) ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 18: 2977-3006. doi:10.1007/s00018-011-0683-9     72 Cited 80 times in Scopus80 0
Lavin, M. F. and Khanna, K. K. (1999) ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia. International Journal of Radiation Biology, 75 10: 1201-1214.     74
Goodarzi, Aaron A, Jonnalagadda, Jyoti C., Douglas, Pauline, Young, David, Ye, Ruiqiong, Moorhead, Greg B. G., Lees-Miller, Susan P. and Khanna, Kum Kum (2004) Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The EMBO Journal, 23 22: 4451-4461. doi:10.1038/sj.emboj.7600455     171 Cited 188 times in Scopus188 4
Lose, Felicity, Arnold, Jeremy, Young, David B., Brown, Carolyn J., Mann, Graham J., Pupo, Gulietta M., Khanna, Kum Kum, Chenevix-Trench, Georgia and Spurdle, Amanda B. (2007) BCoR-L1 variation and breast cancer. Breast Cancer Research, 9 4: 1-12. doi:10.1186/bcr1759     3 Cited 4 times in Scopus4 0
Jung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011) Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 47: 1-14. doi:10.1186/1750-1326-6-47     12 Cited 13 times in Scopus13 0
Jeffery, J., Sinha, D., Srihari, S., Kalimutho, M. and Khanna, K. K. (2015) Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene, 35 6: 683-6390. doi:10.1038/onc.2015.128     28 Cited 30 times in Scopus30 0
Fabbro, Megan, Savage, Kienan, Hobson, Karen, Deans, Andrew J., Powell, Simon N., McArthur, Grant A. and Khanna, Kum Kum (2004) BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. The Journal of Biological Chemistry., 279 30: 31251-31258. doi:10.1074/jbc.M405372200     95 Cited 101 times in Scopus101 3
Kang, Hyo Jin, Kim, Hee Jeong, Kim, Sang Keun, Barouki, Robert, Cho, Chi-Heum, Khanna, Kum Kum, Rosen, Eliot M. and Bae, Insoo (2006) BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. The Journal of Biological Chemistry., 281 21: 14654-14662. doi:10.1074/jbc.M601613200     36 Cited 42 times in Scopus42 1
AL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011) Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 5: 650-658. doi:10.1093/carcin/bgr028     77 Cited 85 times in Scopus85 3
Zhou, B., Chaturvedi, P.S., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R.G., Mattern, M. R., Winkler, J. D. and Khanna, K. K. (2000) Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. Journal of Biological Chemistry, 275 14: 10342-10348. doi:10.1074/jbc.275.14.10342     241 Cited 248 times in Scopus248 12
Khanna, Kum Kum (2000) Cancer risk and the ATM gene: a continuing debate. Journal of the National Cancer Institute, 92 10: 795-802. doi:10.1093/jnci/92.10.795     132 Cited 157 times in Scopus157 3
Fabbro, Megan, Zhou, Bin-Bing, Takahasi, Mikiko, Sarcevic, Boris, Lal, Preeti, Graham, Mark E., Gabrielli, Brian G., Robinson, Phillip J., Nigg, Erich A., Ono, Yoshitaka and Khanna, Kum Kum (2005) Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9 4: 477-488. doi:10.1016/j.devcel.2005.09.003     167 Cited 169 times in Scopus169 6
Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009) Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 14: 2198-2210. doi:10.4161/cc.8.14.8947     74 Cited 76 times in Scopus76 3
Watters, D, Khanna, KK, Beamish, H, Birrell, G, Spring, K, Kedar, P, Gatei, M, Stenzel, D, Hobson, K, Kozlov, S, Zhang, N, Farrell, A, Ramsay, J, Gatti, R and Lavin, M (1997) Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene, 14 16: 1911-1921. doi:10.1038/sj.onc.1201037     158 Cited 158 times in Scopus158 0
Jeffery, Jessie M., Grigoriev, Ilya, Poser, Ina, van der Horst, Armando, Hamilton, Nicholas, Waterhouse, Nigel, Bleier, Jonathan, Subramaniam, V. Nathan, Maly, Ivan V., Akhmanova, Anna and Khanna, Kum Kum (2013) Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment. Cell Cycle, 12 6: 899-906. doi:10.4161/cc.23879     9 Cited 10 times in Scopus10 16
Jeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010) Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 18: 2649-2658. doi:10.1038/onc.2010.37     22 Cited 22 times in Scopus22 0
Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018) CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 9: e8566. doi:10.15252/emmm.201708566     0 Cited 1 times in Scopus1 8
Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D Jo, Bain, Amanda L, Simmons, Jacinta L, Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M, O'Bryan, Moira K and Khanna, Kum Kum (2018) Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 9: fj201701096RR-4999. doi:10.1096/fj.201701096RR     1 0 0
Armando van der Horst, Jacinta Simmons and Kum Kum Khanna (2009) Cep55 stabilization is required for normal execution of cytokinesis. Cell Cycle, 8 22: 3742-3749. doi:10.4161/cc.8.22.10047     17 Cited 21 times in Scopus21 3
Johnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018) Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 1: 179-188. doi:10.1007/s10549-018-4719-9     0 0 3
Waddell, Nic, Jonnalagadda, Jyoti, Marsh, Anna, Grist, Scott, Jenkins, Mark, Hobson, Karen, Taylor, Malcolm, Lindeman, Geoff J., Tavtigian, Sean V., Suthers, Graeme, Goldgar, David, Oefner, Peter J., kConFab Investigators, Taylor, Darrin, Grimmond, Sean, Khanna, Kum Kum and Chenevix-Trench, Georgia (2006) Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. Genes Chromosomes and Cancer, 45 12: 1169-1181. doi:10.1002/gcc.20381     11 Cited 12 times in Scopus12 1
Bruno, Tiziana, De Nicola, Francesca, Iezzi, Simona, Lecis, Daniele, D'Angelo, Carmen, Di Padova, Monica, Corbi, Nicoletta, Dimiziani, Leopoldo, Zannini, Laura, Jekimovs, Christian, Scarsella, Marco, Porrello, Alessandro, Chersi, Alberto, Crescenzi, Marco, Leonetti, Carlo, Khanna, Kum Kum, Soddu, Silvia, Floridi, Aristide, Passananti, Claudio, Domenico Delia and Fanciulli, Maurizio (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell, 10 6: 473-486. doi:10.1016/j.ccr.2006.10.012     72 Cited 84 times in Scopus84 0
Chen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999) CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 1: 249-256. doi:10.1038/sj.onc.1202257     39 Cited 42 times in Scopus42 0
Sorensen, Claus Storgaard, Syluasen, Randi G., Falck, Jacob, Schroeder, Tine, Ronnstrand, Lars, Khanna, Kum Kum, Zhou, Bin-Bing, Bartek, Jiri and Lukas, Jiri (2003) Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3 3: 247-258. doi:10.1016/S1535-6108(03)00048-5     377 Cited 389 times in Scopus389 3
Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001) Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 15: 5214-5222. doi:10.1128/MCB.21.15.5214-5222.2001     167 Cited 171 times in Scopus171 6
Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp and Samuel Refetoff (2009) Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X). Journal of Clinical Endocrinology and Metabolism, 94 10: 4003-4009. doi:10.1210/jc.2009-0686     51 Cited 55 times in Scopus55 1
Scott, SP, Zhang, N, Khanna, KK, Khromykh, A, Hobson, K, Watters, D and Lavin, MF (1998) Cloning and expression of the ataxia-telangiectasia gene in baculovirus. Biochemical and Biophysical Research Communications, 245 1: 144-148. doi:10.1006/bbrc.1998.8137     13 Cited 13 times in Scopus13 6
Srihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014) Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 Supplement 4: . doi:10.1186/1752-0509-8-S4-S1     4 Cited 4 times in Scopus4 1
Lose, Felicity, Arnold, Jeremy, Young, David B., Brown, Carolyn J., Mann, Graham J., Pupo, Gulietta M., Khanna, Kum K., Chenevix-Trench, Georgia and Spurdle, Amanda B. (2008) Correction: BCoR-L1 variation and breast cancer. Breast Cancer Research, 10 5: . doi:10.1186/bcr2153     0
Deans, Andrew J., Khanna, Kum Kum, McNees, Carolyn J., Mercurio, Ciro, Heierhorst, Jörg and McArthur, Grant A. (2006) Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Research, 66 16: 8219-8226. doi:10.1158/0008-5472.CAN-05-3945     80 Cited 80 times in Scopus80 4
Yan, J., Khanna, K. K. and Lavin, M. F. (2000) Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 8: 1025-1035.     Cited 19 times in Scopus19
Khanna, K.K. and Tibbetts, R. (2003) DNA damage response in David N. Cooper (eds.) Nature encyclopedia of the human genome. London, UK: Nature Publishing Group    
Jackson, S.P. and Khanna, K. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 3: 247-254. doi:10.1038/85798     1479 Cited 1584 times in Scopus1584 12
Flanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010) DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 3: 420-433. doi:10.1016/j.ajhg.2010.02.008     58 Cited 66 times in Scopus66 6
Chenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret C., Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R. E., Hopper, John L., Sambrook, Joseph, Mann, Graham J. and Khanna, Kum Kum (2002) Dominant negative ATM mutations in breast cancer families. Journal of the National Cancer Institute, 94 3: 205-215. doi:10.1093/jnci/94.3.205     165 Cited 191 times in Scopus191 7
Henderson, Michelle J., Munoz, Marcia A, Saunders, Darren N., Clancy, Jennifer L., Russell, Amanda J., Williams, Brandi, Pappin, Darryl, Khanna, Kum Kum, Jackson, Stephen P., Sutherland, Robert L. and Watts, Colin K. W. (2006) EDD mediates DNA damage-induced activation of CHK2. Journal of Biological Chemistry, 281 52: 39990-40000. doi:10.1074/jbc.M602818200     39 Cited 40 times in Scopus40 0
Gueven, Nuri, Keatings, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001) EGF sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. The Journal of Biological Chemistry, 276 12: 8884-8891. doi:10.1074/jbc.M006190200     40 Cited 45 times in Scopus45 0

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