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Heath, Alicia K., Williamson, Elizabeth J., Kvaskoff, David, Hodge, Allison M., Ebeling, Peter R., Baglietto, Laura, Neale, Rachel E., Giles, Graham G., Eyles, Darryl W. and English, Dallas R. (2016) 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutrition, 20 10: 1775-1784. doi:10.1017/S1368980016000501     2 Cited 1 times in Scopus1 1
Healy, B., English, K., Mueller, J. and Sly, P. (2015). A case report of plasticizer exposure and asthmatic symptoms during pregnancy. In: Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Gold Coast, Australia, (63-63). 27 March – 1 April 2015. doi:10.1111/resp.12495     0 0
Bertalli, Nadine A., Allen, Katrina J., McLaren, Christine E., Turkovic, Lidija, Osborne, Nicholas J., Constantine, Clare C., Delatycki, Martin B., English, Dallas R., Giles, Graham G., Hopper, John L., Anderson, Gregory J., Olynyk, John K., Powell, Lawrie W., Gurrin, Lyle C. and for the HealthIron Study Investigators (2011) A comparison of self-reported and record-linked blood donation history in an Australian cohort. Transfusion, 51 10: 2189-2198. doi:10.1111/j.1537-2995.2011.03141.x     6 Cited 7 times in Scopus7 0
Gamage, N. W., Hill, D., Whittaker, A. K. and English, A.D. (2001). A mechanistic study of the gaseous products of thermal degradation of fluoropolymers. In: 24 Australasian Polymer Symposium. 24th Austarlasian Polymer Symposium, Beechworth, Vic, (). 4-8 February 2001.    
Wackwella Gamage, N., Hill, D., Whittaker, A. K. and English, A.D. (2001). A mechanistic study of the gaseous products of thermal degradation of perfluoropolymers. In: 24th Australiasian Polymer Symposium. 24th Australiasian Polymer Symposium, Beechworth, Victoria, (A6/2-A6/2). 4-8 February, 2001.    
Dryden, G. M., Sinclair, S. E., Woodford, K. B., English, A. W. and Semiadi, G. (2000) An overview of Sub-Tropical and Tropical deer production systems. Asian-Australasian Journal of Animal Sciences, 13 Supplement Vol C: 62-72.     0
Ong, S. Y., Bertalli, N., Zaloumis, S., Mclaren, C., English, D., Hopper, J., Giles, G., Anderson, G., Olynyk, J., Powell, L., Allen, K., Delatycki, M., Gurrin, L. and Nicoll, A. (2016). Association between arthritis phenotypes and HFE genotypes in the HealthIron study. In: Journal of Gastroenterology and Hepatology. , , (112-113). .     0
English, K., Ryan, J. M., Tobin, L., Murphy, M. J., Barry, F. P. and Mahon, B. P. (2009) Cell contact, prostaglandin E-2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High)forkhead box P3(+) regulatory T cells. Clinical and Experimental Immunology, 156 1: 149-160. doi:10.1111/j.1365-2249.2009.03874.x     333 Cited 341 times in Scopus341 0
Heffernan, A. L., English, K., Toms, L. M. L., Calafat, A. M., Valentin-Blasini, L., Hobson, P., Broomhall, S., Ware, R. S., Jagals, P., Sly, P. D. and Mueller, J. F. (2016) Cross-sectional biomonitoring study of pesticide exposures in Queensland, Australia, using pooled urine samples. Environmental Science and Pollution Research, 23 23: 23436-23448. doi:10.1007/s11356-016-7571-7     4 Cited 6 times in Scopus6 2
Tran, Bich, Armstrong, Bruce K., Ebeling, Peter R., English, Dallas R., Kimlin, Michael G., Van Der Pols, Jolieke C., Venn, Alison, Gebski, Val, Whiteman, David C., Webb, Penelope M. and Neale, Rachel E. (2014) Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial. American Journal of Clinical Nutrition, 99 1: 156-161. doi:10.3945/ajcn.113.063271     20 Cited 19 times in Scopus19 35
Waterhouse, Mary, Tran, Bich, Armstrong, Bruce K., Baxter, Catherine, Ebeling, Peter R., English, Dallas R., Gebski, Val, Hill, Christine, Kimlin, Michael G., Lucas, Robyn M., Venn, Alison, Webb, Penelope M., Whiteman, David C. and Neale, Rachel E. (2014) Environmental, personal, and genetic determinants of response to vitamin D supplementation in older adults. Journal of Clinical Endocrinology and Metabolism, 99 7: E1332-E1340. doi:10.1210/jc.2013-4101     27 Cited 33 times in Scopus33 1
Walsh, Michael D., Clendenning, Mark, Williamson, Elizabeth, Pearson, Sally-Ann, Walters, Rhiannon J., Nagler, Belinda, Packenas, David, Win, Aung K., Hopper, John L., Jenkins, Mark A., Haydon, Andrew M., Rosty, Christophe, English, Dallas R., Giles, Graham G., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013) Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Modern Pathology, 26 12: 1642-1656. doi:10.1038/modpathol.2013.101     53 Cited 55 times in Scopus55 4
Robinson, Matthew R., English, Geoffrey, Moser, Gerhard, Lloyd-Jones, Luke R., Triplett, Marcus A., Zhu, Zhihong, Nolte, Ilja M., Van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Magi, Reedik, Metspalu, Andres, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Johannesson, Magnus, Yang, Jian, Cesarini, David and Visscher, Peter M. (2017) Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 8: 1174-1181. doi:10.1038/ng.3912     14 Cited 13 times in Scopus13 64
Allen, K. J., Gurrin, L. C., Osborne, N. J., Constantine, C. C., Delatycki, M. B., Nicoll, A. J., McLaren, C. E., Bahlo, M., Fletcher, A. S., Nisselle, A. E., Forrest, S., Vulpe, C. D., Anderson, G. J., Giles, G. G., English, D. R., Hopper, J. L., Olynyk, J. K., Powell, L. W. and Gertig, D. M. (2007). Healthiron: a longitudinal population study defining the burden of disease in HFE-associated hereditary hemochromatosis. In: International BioIron Society Abstracts. 2007 International BioIron Society Meeting, Kyoto, Japan, (537-537). 1-6 April 2007. doi:10.1002/ajh.20964     1 0
Gurrin, Lyle C., Bertalli, Nadine A., Dalton, Gregory W., Osborne, Nicholas J., Constantine, Clare C., McLaren, Christine E., English, Dallas R., Gertig, Dorota M., Delatycki, Martin B., Nicoll, Amanda J., Southey, Melissa C., Hopper, John L., Giles, Graham G., Anderson, Gregory J., Olunyk, John K., Powell, Lawrie W. and Allen, Katrina J. (2009) HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology, 50 1: 94-101. doi:10.1002/hep.22972     57 Cited 59 times in Scopus59 1
Osborne, N. J., Gurrin, L. C., Allen, K. J., Constantine, C. C., Delatycki, M. B., Nisselle, A. E., Fletcher, A. R., McLaren, C. E., English, D. R., Hopper, J. L., Giles, G. G., Olynyk, J., Nicoll, A., Powell, L. W. and Gertig, D. M. (2007). Homozygosity for the C282Y mutation in the HFE gene is associated with increased risk of colorectailand breast cancer in Australian population. In: International BioIron Society Abstracts. 2007 International BioIron Society Meeting, Kyoto, Japan, (575-575). 1-6 April 2007. doi:10.1002/ajh.20964     2 0
Gurrin, L. C., Allen, K. J., Osborne, N. J., Constantine, C. C., Delatycki, M. B., Nisselle, A. E., Fletcher, A. R., McLaren, C. E., Anderson, G. J., English, D. R., Hopper, J. L., Giles, G. G., Olynyk, J., Nicoll, A., Powell, L. W. and Gertig, D. M. (2007). Iron measures at baseline and follow-up from a longitudinal study of modifiers of hereditary haemochromatosis: the healthiron study. In: International BioIron Society Abstracts. 2007 International BioIron Society Meeting, Kyoto, Japan, (537-537). 1-6 April 2007. doi:10.1002/ajh.20964     0 0
Allen, Katrina J., Gurrin, Lyle C., Constantine, Clare C., Osborne, Nicholas J., Delatycki, Martin B., Nicoll, Amanda J., McLaren, Christine E., Bahlo, Melanie, Nisselle, Amy E., Vulpe, Chris D., Anderson, Gregory J., Southey, Melissa C., Giles, Graham G., English, Dallas R., Hopper, John L., Olynyk, John K., Powell, Lawrie W. and Gertig, Dorota M. (2008) Iron-overload-related disease in HFE hereditary hemochromatosis. New England Journal of Medicine, 358 3: 221-230. doi:10.1056/NEJMoa073286     372 Cited 406 times in Scopus406 37
Heath, Alicia K., Williamson, Elizabeth J., Ebeling, Peter R., Kvaskoff, David, Eyles, Darryl W and English, Dallas R. (2014) Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in Plasma. Journal of Clinical Endocrinology and Metabolism, 99 9: 3319-3324. doi:10.1210/jc.2014-1269     19 Cited 19 times in Scopus19 2
Wagner, G. N., Hinch, S. G., Kuchel, L. J., Lotto, A., Jones, S. R. M., Patterson, D. A., Macdonald, J. S., Van der Kraak, G., Shrimpton, M., English, K. K., Larsson, S., Cooke, S. J., Healy, M. C. and Farrell, A. P. (2005) Metabolic rates and swimming performance of adult Fraser River sockeye salmon (Oncorhynchus nerka) after a controlled infection with Parvicapsula minibicornis. Canadian Journal of Fisheries And Aquatic Sciences, 62 9: 2124-2133. doi:10.1139/F05-126     71 Cited 74 times in Scopus74 0
Kvaskoff, David, Heath, Alicia K., Simila, Henry A., Ko, Pauline, English, Dallas R. and Eyles, Darryl W. (2016) Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS. Clinical Chemistry, 62 4: 639-646. doi:10.1373/clinchem.2015.251538     8 Cited 7 times in Scopus7 1
Zaloumis, Sophie G., Allen, Katrina J., Bertalli, Nadine A., Turkovic, Lidija, Delatycki, Martin B., Nicoll, Amanda J., McLaren, Christine E., English, Dallas R., Hopper, John L., Giles, Graham G., Anderson, Gregory J., Olynyk, John K., Powell, Lawrie W. and Gurrin, Lyle C. (2015) Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study. Journal of Gastroenterology and Hepatology (Australia), 30 4: 719-725. doi:10.1111/jgh.12804     13 Cited 13 times in Scopus13 2
Rosty, C., Young, J. P., Walsh, M. D., Clendenning, M., Jenkins, M. A., Win, A. K., Southey, M. C., Parry, S., Hopper, J. L., Giles, G. G., Williamson, E., English, D. R. and Buchanan, D. D. (2013). PIK3CA activating mutation in colorectal carcinoma: a stratified analysis in a prospective cohort. In: The 102nd USCAP Annual Meeting Abstracts. 102nd Annual Meeting of the United-States and Canadian Academy of Pathology (USCAP), Baltimore Maryland, USA, (175A-176A). 02-08 March 2013. doi:10.1038/modpathol.2013.9     0 0
Rosty, C., Young, J. P., Walsh, M. D., Clendenning, M., Jenkins, M. A., Win, A. K., Southey, M. C., Parry, S., Hopper, J. L., Giles, G. G., Williamson, E., English, D. R. and Buchanan, D. D. (2013). PIK3CA Activating Mutation in Colorectal Carcinoma: A Stratified Analysis in a Prospective Cohort. In: 102nd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), Baltimore Md, (175A-176A). 2 - 8 March 2013. doi:10.1038/labinvest.2013.20     0 0
Tran B., Armstrong B.K., McGeechan K., Ebeling P.R., English D.R., Kimlin M.G., Lucas R., Van Der Pols J.C., Venn A., Gebski V., Whiteman D.C., Webb P.M. and Neale R.E. (2013) Predicting vitamin D deficiency in older Australian adults. Clinical Endocrinology, 79 5: 631-640. doi:10.1111/cen.12203     19 Cited 24 times in Scopus24 2
Lam, S., Myers, R., Atkar-Khattra, S., Yuan, R., Yee, J., English, J., Grant, K., Lee, A., Mcguire, A., McWilliams, A., Brims, F., Stone, E., Chin, V., Chantrill, L., Connellan, M., Plitt, M., Marshall, H., Yang, I., Bowman, R., Fong, K. and Mayo, J. (2018). Prospective Evaluation of the Clinical Utility of the International Lung Screen Trial Lung Nodule Management Protocol. In: , , (S362-S363). . doi:10.1016/j.jtho.2018.08.332     0 0
Jones, J.D.G., Bishop, G., Carroll, B., Dickinson, M., English, J., Harrison, K. and Jones, D. (1992) Prospects for establishing a tomato gene tagging system using the maize transposon activator (Ac). Proceedings of the Royal Society of Edinburgh Section B-Biological Sciences, 99 107-119.     13
Coulthard, A, Hall, K, English, P T, Ince, P G, Burn, D J and Bates, D (1999) Quantitative analysis of MRI signal intensity in new variant Creutzfeldt-Jakob disease. The British Journal of Radiology, 72 860: 742-748. doi:10.1259/bjr.72.860.10624339     6
English, Annie K., Chauvenet, Alienor L. M., Safi, Kamran and Pettorelli, Nathalie (2012) Reassessing the determinants of breeding synchrony in Ungulates. PLoS One, 7 7: e41444-e41444. doi:10.1371/journal.pone.0041444     224 Cited 16 times in Scopus16 5
Tran, Bich, Armstrong, Bruce K., Carlin, John B., Ebeling, Peter R., English, Dallas R., Kimlin, Michael G., Rahman, Bayzidur, van der Pols, Jolieke C., Venn, Alison, Gebski, Val, Whiteman, David C., Webb, Penelope M. and Neale, Rachel E. (2012) Recruitment and results of a pilot trial of vitamin D supplementation in the general population of Australia. Journal of Clinical Endocrinology and Metabolism, 97 12: 4473-4480. doi:10.1210/jc.2012-2682     13 Cited 15 times in Scopus15 1
Rosty, Christophe, Wiliamson, Elizabeth J., Clendening, Mark, Walters, Rhianon J., Walsh, Michael D., Win, Aung K., Jenkins, Mark A., Hoper, John L., Winship, Ingrid, Southey, Melisa C., Giles, Graham G., English, Dalas R. and Buchanan, Daniel D. (2014) Re: Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. JNCI Journal of the National Cancer Institute, 106 8: . doi:10.1093/jnci/dju180     1 Cited 5 times in Scopus5 1
Buchanan, Daniel D., Sweet, Kevin, Drini, Musa, Jenkins, Mark A., Win, Aung Ko, English, Dallas R., Walsh, Michael D., Clendenning, Mark, McKeone, Diane M., Walters, Rhiannon J., Roberts, Aedan, Pearson, Sally-Ann, Pavluk, Erika, Hopper, John L., Gattas, Michael R., Goldblatt, Jack, George, Jill, Suthers, Graeme K., Phillips, Kerry D., Woodall, Sonja, Arnold, Julie, Tucker, Kathy, Muir, Amanda, Field, Michael, Greening, Sian, Gallinger, Steven, Perrier, Renee, Baron, John A., Potter, John D., Haile, Robert, Frankel, Wendy, de la Chapelle, Albert, Macrae, Finlay, Rosty, Christophe, Walker, Neal I., Parry, Susan and Young, Joanne P. (2010) Risk factors for colorectal cancer in patients with multiple serrated polyps: A cross-sectional case series from genetics clinics. PLoS One, 5 7: e11636-1-e11636-7. doi:10.1371/journal.pone.0011636     45 Cited 47 times in Scopus47 0
Rosty, C., Young, J. P., Walsh, M. D., Walters, R., Jenkins, M. A., Win, A. K., Southey, M. C., Parry, S., Hopper, J. L., Giles, G. G., English, D. R. and Buchanan, D. D. (2013). Serrated pathway colorectal carcinoma without microsatellite instability demonstrates Aggressive features and is associated with poor overall survival. In: The 102nd USCAP Annual Meeting Abstracts. 102nd Annual Meeting of the United-States and Canadian Academy of Pathology (USCAP), Baltimore Maryland, USA, (176A-176A). 02-08 March 2013. doi:10.1038/modpathol.2013.9     0 0
Rosty, C., Young, J. P., Walsh, M. D., Walters, R., Jenkins, M. A., Win, A. K., Southey, M. C., Parry, S., Hopper, J. L., Giles, G. G., English, D. R. and Buchanan, D. D. (2013). Serrated Pathway Colorectal Carcinoma without Microsatellite Instability Demonstrates Aggressive Features and Is Associated with Poor Overall Survival. In: 102nd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), Baltimore Md, (176A-176A). 2 - 8 March 2013. doi:10.1038/labinvest.2013.20     0 0
Rosty, Christophe, Williamson, Elizabeth J., Clendenning, Mark, Walters, Rhiannon J., Win, Aung K., Jenkins, Mark A., Hopper, John L., Winship, Ingrid M., Southey, Melissa C., Giles, Graham G., English, Dallas R. and Buchanan, Daniel D. (2014) Should the grading of colorectal adenocarcinoma include microsatellite instability status?. Human Pathology, 45 10: 2077-2084. doi:10.1016/j.humpath.2014.06.020     25 Cited 28 times in Scopus28 1
English, Coralie, Healy, Genevieve N., Coates, Alison, Lewis, Lucy K., Olds, Tim and Bernhardt, Julie (2016) Sitting time and physical activity after stroke: physical ability is only part of the story. Topics in Stroke Rehabilitation, 23 1: 62-68. doi:10.1179/1945511915Y.0000000009     8 Cited 11 times in Scopus11 16
Lewis, L. K., Rowlands, A. V., Gardiner, P. A., Standage, M., English, C. and Olds, T. (2016) Small steps: preliminary effectiveness and feasibility of an incremental goal-setting intervention to reduce sitting time in older adults. Maturitas, 85 64-70. doi:10.1016/j.maturitas.2015.12.014     10 Cited 11 times in Scopus11 20
Clendenning, Mark, Huang, Alvin, Jayasekara, Harindra, Lorans, Marie, Preston, Susan, O'Callaghan, Neil, Pope, Bernard J., Macrae, Finlay A., Winship, Ingrid M., Milne, Roger L., Giles, Graham G., English, Dallas R., Hopper, John L., Win, Aung K., Jenkins, Mark A., Southey, Melissa C., Rosty, Christophe and Buchanan, Daniel D. (2017) Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas. Familial Cancer, 17 1: 91-100. doi:10.1007/s10689-017-0013-y     0 Cited 1 times in Scopus1 1
Lynch, Brigid M., Nguyen, Nga H., Reeves, Marina M., Moore, Melissa M., Rosenberg, Dori E., Wheeler, Michael J., Boyle, Terry, Vallance, Jeff K., Friedenreich, Christine M. and English, Dallas R. (2017) Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial. Contemporary Clinical Trials, 64 112-117. doi:10.1016/j.cct.2017.10.015     0 0 1
Gomersall, S. R., Maher, C., English, C., Rowlands, A. V., Dollman, J., Norton, K. and Olds, T. (2016) Testing the activitystat hypothesis: a randomised controlled trial. BMC Public Health, 16 1: 900. doi:10.1186/s12889-016-3568-x     6 Cited 7 times in Scopus7 3
Neale, R. E., Armstrong, B. K., Baxter, C., Duarte Romero, B., Ebeling, P., English, D. R., Kimlin, M. G., McLeod, D. S. A., O'Connell, R. L., van der Pols, J. C., Venn, A. J., Webb, P. M., Whiteman, D. C. and Wockner, L. (2016) The D-Health Trial: a randomized trial of vitamin D for prevention of mortality and cancer. Contemporary Clinical Trials, 48 83-90. doi:10.1016/j.cct.2016.04.005     19 Cited 27 times in Scopus27 3
Gurrin, Lyle C., Osborne, Nicholas J., Constantine, Clare C., McLaren, Christine E., English, Dallas R., Gertig, Dorota M., Delatycki, Martin B., Southey, Melissa C., Hopper, John L., Giles, Graham G., Anderson, Gregory J., Olynyk, John K., Powell, Laurie W. and Allen, Katrina J. (2008) The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis. Gastroenterology, 135 6: 1945-1952. doi:10.1053/j.gastro.2008.08.056     55 Cited 64 times in Scopus64 0
Gross, I., Morrison, D. J., Hyink, D. P., Georgas, K., English, M. A., Mericskay, M., Hosono, S., Sasson, D., Wilson, P. D., Little, M. and Licht, J. D. (2003) The receptor tyrosine kinase regulator sprouty1 is a target of the tumor suppressor WT1 and important for kidney development. Journal of Biological Chemistry, 278 42: 41420-41430. doi:10.1074/jbc.M306425200     49 Cited 53 times in Scopus53 3
English, A.D., Hill, D., Gamage, N. W., Lonsdale, M. K., Shao, L. and Whittaker, A. K. (2001). The thermal degradation of FEP fluoropolymers. In: 7th Pacfic Polymer Conference. 7th Pacific Polymer Conference, Oaxaca, Mexico, (32-32). 3-7 December, 2001.    
Heath, Alicia K., Williamson, Elizabeth J., Hodge, Allison M., Ebeling, Peter R., Eyles, Darryl W., Kvaskoff, David, O'Dea, Kerin, Giles, Graham G. and English, Dallas R. (2018) Vitamin D status and the risk of type 2 diabetes: the Melbourne Collaborative Cohort Study. Diabetes Research and Clinical Practice, . doi:10.1016/j.diabres.2018.05.007     4
Krawczynski, Henric S., Stern, Daniel, Harrison, Fiona A., Kislat, Fabian F., Zajczyk, Anna, Beilicke, Matthias, Hoormann, Janie, Guo, Qingzhen, Endsley, Ryan, Ingram, Adam R., Miyasaka, Hiromasa, Madsen, Kristin K., Aaron, Kim M., Amini, Rashied, Baring, Matthew G., Beheshtipour, Banafsheh, Bodaghee, Arash, Booth, Jeffrey, Borden, Chester, Boettcher, Markus, Christensen, Finn E., Coppi, Paolo S., Cowsik, Ramanath, Davis, Shane, Dexter, Jason, Done, Chris, Dominguez, Luis A., Ellison, Don, English, Robin J., Fabian, Andrew C., Falcone, Abe, Favretto, Jeffrey A., Fernandez, Rodrigo, Giommi, Paolo, Grefenstette, Brian W., Kara, Erin, Lee, Chung H., Lyutikov, Maxim, Maccarone, Thomas, Matsumoto, Hironori, McKinney, Jonathan, Mihara, Tatehiro, Miller, Jon M., Narayan, Ramesh, Natalucci, Lorenzo, Oezel, Feryal, Pivovaroff, Michael J., Pravdo, Steven, Psaltis, Dimitrios, Okajima, Takashi, Toma, Kenji and Zhang, William W. (2016) X-ray polarimetry with the Polarization Spectroscopic Telescope Array (PolSTAR). Astroparticle Physics, 75 8-28. doi:10.1016/j.astropartphys.2015.10.009     15 Cited 14 times in Scopus14 1