Gentamicin Dosage Intervals In Neonates: Longer Dosage Interval - Less Toxicity

Davies, M. W. and Cartwright, D. W. (1998) Gentamicin Dosage Intervals In Neonates: Longer Dosage Interval - Less Toxicity. Journal of Paediatrics and Child Health, 34 6: 577-580. doi:10.1046/j.1440-1754.1998.00306.x

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Author Davies, M. W.
Cartwright, D. W.
Title Gentamicin Dosage Intervals In Neonates: Longer Dosage Interval - Less Toxicity
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
Publication date 1998-12-01
Year available 1998
Sub-type Article (original research)
DOI 10.1046/j.1440-1754.1998.00306.x
Volume 34
Issue 6
Start page 577
End page 580
Total pages 4
Language eng
Subject 321019 Paediatrics
321210 Community Child Health
Abstract Objectives: The aim of this study was to determine the incidence of toxic trough serum gentamicin levels in neonates in the first week of life, with different dosage intervals. Methods: This was a retrospective study of neonates born between 01.07.95 and 31.12.95, who received gentamicin. Data were collected on birth weight, gestation, gentamicin dose, the trough level of gentamicin, serum creatinine and urine output. A trough serum gentamicin level of greater than or equal to 1.5 mg/L was considered toxic. Results: One hundred and seventy infants met the study criteria. All 21 infants in group one (2429 weeks) received gentamicin with a dosage interval of 24 h. Sixteen (76%) infants had toxic trough serum gentamicin levels. In group two (3034 weeks) 8 infants had gentamicin q12hly and all (100%) had toxic trough serum gentamicin levels. Fourteen infants had gentamicin every 18 h and 13 (93%) had toxic trough serum gentamicin levels. Sixty-one infants had gentamicin q24hly and 25 (41%) had toxic trough serum gentamicin levels. The differences in proportions with toxic levels were statistically significant. In group three (greater than or equal to 35 weeks) 29 infants had gentamicin q12hly and 25 (86%) had toxic trough serum gentamicin levels. Six infants had gentamicin every 18 h and 2 (33%) had toxic trough serum gentamicin levels. Thirty-one infants had gentamicin q24hly and 4 (13%) had toxic trough serum gentamicin levels. The differences in proportions comparing infants having gentamicin q12hly with those having it q24hly were statistically significant. Conclusions: A starting gentamicin dosage interval of 12 h in infants of any gestational age, or a starting dosage interval of 24 h for infants of less than 30 weeks gestational age, leads to most having toxic trough serum gentamicin levels. In infants of 30 weeks gestational age or greater, most have safe non-toxic trough serum gentamicin levels if started on a dosage interval of 24 h.
Keyword drug administration schedule
drug monitoring
drug toxicity
gentamicins
Gentamicins
Infant
Newborn
Aminoglycoside Therapy
Gestational-age
Serum Levels
Infants
Ototoxicity
neonates
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Originally published as MW Davies and DW Cartwright (1998) Gentamicin dosage intervals in neonates: Longer dosage interval - less toxicity, J. Paediatr. Child Health (1998) 34 (6), 577-580. Copyright 1998 Blackwell Publishing. All rights reserved.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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