Effects of Enzyme Induction on Metabolism of Prednisolone

Brooks, P. M., Grove, M. and Downie, W. W. (1976) Effects of Enzyme Induction on Metabolism of Prednisolone. Annals of the Rheumatic Diseases, 35 4: 339-343. doi:10.1136/ard.35.4.339

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Author Brooks, P. M.
Grove, M.
Downie, W. W.
Title Effects of Enzyme Induction on Metabolism of Prednisolone
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1136/ard.35.4.339
Open Access Status File (Author Post-print)
Volume 35
Issue 4
Start page 339
End page 343
Total pages 5
Language eng
Subject 321028 Rheumatology and Arthritis
320503 Clinical Pharmacology and Therapeutics
Abstract The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy.
Keyword rheumatoid arthritis
drug therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Originally published as Brooks PM, Buchanan WW, Grove M, Downie WW. Effects of Enzyme Induction on Metabolism of Prednisolone. Ann Rheum Dis 1976; 35: 339-43 Copied with permission of BMJ.

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biomedical Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 42 times in Thomson Reuters Web of Science Article | Citations
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