Indomethacin/aspirin interaction: a clinical appraisal

Brooks, P. M., Walker, J. J., Bell, M. A., Buchanan, W. W. and Rhymer, A. R. (1975) Indomethacin/aspirin interaction: a clinical appraisal. BMJ, 3 5975: 69-71. doi:10.1136/bmj.3.5975.69

Author Brooks, P. M.
Walker, J. J.
Bell, M. A.
Buchanan, W. W.
Rhymer, A. R.
Title Indomethacin/aspirin interaction: a clinical appraisal
Journal name BMJ   Check publisher's open access policy
ISSN 0959-8138
Publication date 1975-01-01
Sub-type Article (original research)
DOI 10.1136/bmj.3.5975.69
Open Access Status DOI
Volume 3
Issue 5975
Start page 69
End page 71
Total pages 3
Language eng
Abstract Plasma profiles of indomethacin after a 50-mg oral dose were constructed in six healthy volunteers before and after a week of aspirin treatment. Aspirin did not interfere with indomethacin plasma levels. To examine the clinical effect of concurrent indomethacin and aspirin treatment 20 patients with seropositive rheumatoid arthritis were given indomethacin 100 mg/day, aspirin soluble 4 g/day, and the two drugs taken together in random order. Analysis of the clinical indices of inflammation - articular index and mean pain score - and of the efficacy of each treatment showed no significant differences between the three treatment groups. With the proliferation in the number of anti-rheumatic drugs available, the case for giving two or more nonsteroidal anti-inflammatory drugs concurrently remains unproved.
Keyword Indomethacin
Rheumatoid drug therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Originally published as Brooks PM, Walker JJ, Bell MA, Buchanan WW, Rhymer AR. Indomethacin/Aspirin Interaction: a Clinical Appraisal. Brit Med J 1975; 3:69-71 Copied with permission of BMJ.

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biomedical Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
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