Purpose/Objectives: To explore the phenomenon of isolation from the perspective of patients cared for in reverse isolation for bone marrow transplant (BMT). Design: Interpretive, phenomenologic. Setting: Hematology and bone marrow transplant unit of a large teaching hospital in Brisbane, Australia. Sample: Seven patients undergoing BMT. Method: Phenomenologic interviews and thematic analysis of transcribed data. Main Research Variable: Patients' day-to-day experiences of reverse isolation. Findings: Although appreciative of the physical care and attention given to them, participants did not convey a sense that healthcare professionals understood from their perspective. Major themes elicited from analysis of the transcripts included (a) striving to take charge, which refers to participants' attempts to mantain control in a seemingly out-of-control situation, (b) intellectualizing the need for isolation, and (c) being in touch contact with family and staff. Conclusions: Elements of caring for the patient appeared to dominate the comments associated with staff contact. Other forms of care (e.g. caring about) emphasize the importance of nurses understanding and connecting with peoples' meanings and experiences of their illness and treatment. Implications for Nursing Practice: Although all participants were aware that they could ask for information about their diagnosis and treatment at any time, most had not been offered the opportunity to describe their feelings or experiences before. Unless nurses take more initiative to gain insight and greater appreciation of the patient's understanding of his or her sitaution, they will continue to focus on unidimensional aspects of care and neglect the multidimensional or holistic nature of nursing care.