Scaleup of wet granulation processes: science not art

Litster, J. D. (2003). Scaleup of wet granulation processes: science not art. In: Powder Technology : Proceedings o f the 7th International Symposium on Agglomeration. 7th International Symposium on Agglomeration, Albi, France, (35-40). 29-31 May 2001. doi:10.1016/S0032-5910(02)00222-X


Author Litster, J. D.
Title of paper Scaleup of wet granulation processes: science not art
Conference name 7th International Symposium on Agglomeration
Conference location Albi, France
Conference dates 29-31 May 2001
Proceedings title Powder Technology : Proceedings o f the 7th International Symposium on Agglomeration   Check publisher's open access policy
Journal name Powder Technology   Check publisher's open access policy
Place of Publication Lausanne, Switzerland
Publisher Elsevier
Publication Year 2003
Sub-type Fully published paper
DOI 10.1016/S0032-5910(02)00222-X
ISSN 0032-5910
Volume 130
Issue 1-3
Start page 35
End page 40
Total pages 6
Collection year 2003
Language eng
Abstract/Summary Significant advances have been made in the last decade to quantify the process of wet granulation. The attributes of product granules from the granulation process are controlled by a combination of three groups of processes occurring in the granulator: (1) wetting and nucleation, (2) growth and consolidation and (3) breakage and attrition. For the first two of these processes, the key controlling dimensionless groups are defined and regime maps are presented and validated with data from tumbling and mixer granulators. Granulation is an example of particle design. For quantitative analysis, both careful characterisation of the feed formulation and knowledge of operating parameters are required. A key thesis of this paper is that the design, scaleup and operation of granulation processes can now be considered as quantitative engineering rather than a black art. Résumé
Subjects E1
090499 Chemical Engineering not elsewhere classified
Keyword Wetting
Attrition
Particle design
Q-Index Code E1

Document type: Conference Paper
Collection: School of Chemical Engineering Publications
 
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Created: Fri, 24 Aug 2007, 10:28:33 EST