Demyelination and Nerve Conduction Abnormalities in Acute and Chronic Experimental Allergic Encephalomyelitis in the Lewis Rat

Pender, M. P., Nguyen, K. B., Stanley, G. P. and Yoong, G. (1990). Demyelination and Nerve Conduction Abnormalities in Acute and Chronic Experimental Allergic Encephalomyelitis in the Lewis Rat. In: Takeshi Yonezawa, Satellite Symposium (Demyelination: Mechanisms and Background) of the XIth International Congress of Neuropathology. XIth International Congress of Neuropathology, Kyoto, Japan, (50-55). 9-11 September, 1990.

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Author Pender, M. P.
Nguyen, K. B.
Stanley, G. P.
Yoong, G.
Title of paper Demyelination and Nerve Conduction Abnormalities in Acute and Chronic Experimental Allergic Encephalomyelitis in the Lewis Rat
Conference name XIth International Congress of Neuropathology
Conference location Kyoto, Japan
Conference dates 9-11 September, 1990
Proceedings title Satellite Symposium (Demyelination: Mechanisms and Background) of the XIth International Congress of Neuropathology
Publication Year 1990
Sub-type Fully published paper
Editor Takeshi Yonezawa
Start page 50
End page 55
Abstract/Summary We have been using histological and electrophysiological techniques to compare the pathology and pathophysiology in different forms of experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE induced by sensitization to myelin basic protein (MBP) or by the passive transfer of MBP-specific lymphocytes, there is inflammation and demyelination in the ventral and dorsal spinal roots and inflammation and limited demyelination in the spinal cord. More extensive spinal cord demyelination as well as demyelination in the spinal roots and ganglia is observed in acute EAE induced by inoculation with whole central nervous system (CNS) tissue. In chronic relapsing EAE induced by inoculation with whole CNS tissue and treatment with low dose cyclosporin A, large plaques of spinal cord demyelination occur in rats with clinical episodes >28 days after inoculation. In rats with clinical disease <25 days after inoculation there is prominent demyelination in the spinal roots and ganglia as well as in the spinal cord. In all 4 forms of EAE, peripheral nervous system (PNS) remyelination by Schwann cells and CNS remyelination by oligodendrocytes occurs during clinical recovery. Electrophysiological studies revealed PNS and CNS nerve conduction abnormalities during clinical episodes, with improvement during remissions.
Subjects 320702 Central Nervous System
321013 Neurology and Neuromuscular Diseases
Keyword Demyelination
Experimental allergic encephalomyelitis
Nerve conduction
Remyelination
Lewis rat
Experimental autoimmune encephalomyelitis
EAE
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Wed, 06 Apr 2005, 10:00:00 EST