Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis

Nguyen, Kim B., McCombe, Pamela A. and Pender, Michael P. (1994) Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 7 2: 145-152. doi:10.1006/jaut.1994.1011

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Author Nguyen, Kim B.
McCombe, Pamela A.
Pender, Michael P.
Title Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis
Journal name Journal of Autoimmunity   Check publisher's open access policy
ISSN 0896-8411
Publication date 1994-04-01
Sub-type Article (original research)
DOI 10.1006/jaut.1994.1011
Open Access Status File (Author Post-print)
Volume 7
Issue 2
Start page 145
End page 152
Total pages 8
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Subject 320702 Central Nervous System
320207 Autoimmunity
Abstract Using light and electron microscopy, we have demonstrated that macrophage apoptosis (programmed cell death) occurs in the central nervous system (CNS) in Lewis rats with acute experimental autoimmune encephalomyelitis (EAE) and chronic relapsing EAE. Apoptotic macrophages were identified by the presence of an apoptotic nucleus in a cell with cytoplasm containing myelin debris but no intermediate filaments. They were found in the meninges, perivascular spaces and in the parenchyma of the white and grey matter of the spinal cord. In acute EAE the apoptotic macrophages were most frequently seen at the time of maximal neurological signs and during the early stages of clinical recovery. Several possible mechanisms may be responsible for the macrophage apoptosis: the release or withdrawal of cytokines; T-cell cytotoxicity; the effect of activated macrophage products, such as nitric oxide; and a direct effect of endogenous glucocorticoids. Macrophage apoptosis, together with the T-cell apoptosis we have previously described in the CNS in EAE, may contribute to the down-regulation of this autoimmune disease.
Keyword Apoptosis
Cell death
Central nervous system
Acute experimental autoimmune encephalomyelitis
Experimental allergic encephalomyelitis
Q-Index Code C1
Additional Notes This is an author version of an article originally published as Kim B. Nguyen, Pamela A. McCombe and Michael P. Pender (1994) Macrophage Apoptosis in the Central Nervous System in Experimental Autoimmune Encephalomyelitis, Journal of Autoimmunity, 7 (2): 145-152. doi: Copyright 1994 Elsevier Ltd. All rights reserved. Single copies only may be downloaded and printed for a user’s personal research and study.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 78 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 06 Jun 2005, 10:00:00 EST