Evolving noisy oscillatory dynamics in genetic regulatory networks

Leier, Andre, Kuo, P. Dwight, Banzhaf, Wolfgang and Burrage, Kevin (2006). Evolving noisy oscillatory dynamics in genetic regulatory networks. In: P. Collet, M. Tomassini, M. Ebner, S. Gustafson and A. Ekart, Lecture Notes in Computer Science: Genetic Programming. 9th European Conference on Genetic Programming EuroGP2006, Budapest, Hungary, (290-299). 10-12 April, 2004. doi:10.1007/11729976_26

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Author Leier, Andre
Kuo, P. Dwight
Banzhaf, Wolfgang
Burrage, Kevin
Title of paper Evolving noisy oscillatory dynamics in genetic regulatory networks
Conference name 9th European Conference on Genetic Programming EuroGP2006
Conference location Budapest, Hungary
Conference dates 10-12 April, 2004
Proceedings title Lecture Notes in Computer Science: Genetic Programming   Check publisher's open access policy
Journal name Genetic Programming, Proceedings   Check publisher's open access policy
Place of Publication Berlin ; New York
Publisher Springer
Publication Year 2006
Sub-type Fully published paper
DOI 10.1007/11729976_26
ISBN 978-3-540-33143-8
ISSN 0302-9743
Editor P. Collet
M. Tomassini
M. Ebner
S. Gustafson
A. Ekart
Volume 3905
Start page 290
End page 299
Total pages 10
Language eng
Abstract/Summary We introduce a genetic programming (GP) approach for evolving genetic networks that demonstrate desired dynamics when simulated as a discrete stochastic process. Our representation of genetic networks is based on a biochemical reaction model including key elements such as transcription, translation and post-translational modifications. The stochastic, reaction-based GP system is similar but not identical with algorithmic chemistries. We evolved genetic networks with noisy oscillatory dynamics. The results show the practicality of evolving particular dynamics in gene regulatory networks when modelled with intrinsic noise.
Subjects 060102 Bioinformatics
Keyword Computer Science, Theory & Methods
Stochastic Simulation
Escherichia-coli
Expression
Evolution
Cells
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Subseries: Theoretical Computer Science and General Issues

 
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Created: Mon, 20 Aug 2007, 06:35:51 EST