Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein

Chalk, Jonathan B., McCombe, Pamela A. and Pender, Michael P. (1994) Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein. Brain, 117 5: 975-986. doi:10.1093/brain/117.5.975

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Author Chalk, Jonathan B.
McCombe, Pamela A.
Pender, Michael P.
Title Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein
Journal name Brain   Check publisher's open access policy
ISSN 0006-8950
1460-2156
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1093/brain/117.5.975
Open Access Status File (Author Post-print)
Volume 117
Issue 5
Start page 975
End page 986
Total pages 12
Place of publication London, U.K.
Publisher Oxford University Press
Language eng
Subject 320200 Immunology
321013 Neurology and Neuromuscular Diseases
320207 Autoimmunity
Abstract Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) and can be induced by inoculation of animals with homogenized CNS tissue or highly purified myelin proteins such as myelin basic protein (MBP) or proteolipid protein (PLP). It is widely studied as a possible animal model of multiple sclerosis. We performed the present neurophysiological study to define the location of nerve conduction abnormalities in EAE induced by immunization with PLP (PLP-EAE) and in EAE induced by immunization with MBP (MBP-EAE) in the Lewis rat. In rats with tail weakness due to acute PLP-EAE, conduction was normal in the spinal nerve roots and peripheral nerves but there was evidence of conduction block in a high proportion of the fibres in the dorsal columns of the lumbosacral spinal cord. In contrast, in acute MBP-EAE, there was conduction block in a high proportion of fibres in the sacral dorsal and ventral roots of the peripheral nervous system (PNS) and in the dorsal columns of the lumbosacral spinal cord. The distribution of nerve conduction abnormalities is consistent with previous histological studies showing that inflammation and primary demyelination are restricted to the CNS in PLP-EAE, but are present in the CNS and in the spinal roots of the PNS in MBP-EAE. The restriction of functional abnormalities to the CNS in PLP-EAE but not in MBP-EAE may have implications for the human inflammatory demyelinating diseases, including multiple sclerosis.
Keyword Experimental autoimmune encephalomyelitis
Multiple sclerosis
Myelin basic protein
Neurophysiology
Proteolipid protein
Experimental allergic encephalomyelitis
EAE
MBP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes This is an author-produced PDF of an article published in Brain. The definitive publisher-authenticated version of JB Chalk, PA McCombe and MP Pender (1994) Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein, Brain, 117 (5) : 975-986 is available online at: http://brain.oxfordjournals.org/cgi/content/abstract/117/5/975. Copyright 1994 by Oxford University Press. All rights reserved. Please Note: In the original published article, the intraperitoneal (i.p.) injection of ketamine (in the section Electrophysiological studies - Preparation of animals) was incorrectly reported as 15 mg/kg. It has been corrected to 74 mg/kg in this version.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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