T Cells Augment Monocyte and Neutrophil Function in Host Resistance against Oropharyngeal Candidiasis

Farah, C. S., Elahi, S., Pang, G., Gotjamanos, T., Seymour, G. J., Clancy, R. L. and Ashman, R. B. (2001) T Cells Augment Monocyte and Neutrophil Function in Host Resistance against Oropharyngeal Candidiasis. Infection and Immunity, 69 10: 6110-6118. doi:10.1128/IAI.69.10.6110-6118.2001

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Author Farah, C. S.
Elahi, S.
Pang, G.
Gotjamanos, T.
Seymour, G. J.
Clancy, R. L.
Ashman, R. B.
Title T Cells Augment Monocyte and Neutrophil Function in Host Resistance against Oropharyngeal Candidiasis
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2001-10
Sub-type Article (original research)
DOI 10.1128/IAI.69.10.6110-6118.2001
Open Access Status File (Publisher version)
Volume 69
Issue 10
Start page 6110
End page 6118
Total pages 9
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract The purpose of this study was to identify the cell populations involved in recovery from oral infections with Candida albicans. Monoclonal antibodies specific for CD4 cells, CD8 cells, and polymorphonuclear leukocytes were used to deplete BALB/c and CBA/CaH mice of the relevant cell populations in systemic circulation. Monocytes were inactivated with the cytotoxic chemical carrageenan. Mice were infected with 108 C. albicans yeast cells and monitored for 21 days. Systemic depletion of CD4 and CD8 T lymphocytes alone did not increase the severity of oral infection compared to that of controls. Oral colonization persisted in animals treated with head and neck irradiation and depleted of CD4 T cells, whereas infections in animals that received head and neck irradiation alone or irradiation and anti-CD8 antibody cleared the infection in a comparable fashion. The depletion of polymorphonuclear cells and the cytotoxic inactivation of mononuclear phagocytes significantly increased the severity of oral infection in both BALB/c and CBA/CaH mice. High levels of interleukin 12 (IL-12) and gamma interferon (IFN-gamma) were produced by lymphocytes from the draining lymph nodes of recovering animals, whereas IL-6, tumor necrosis factor alpha, and IFN-gamma were detected in the oral mucosae of both naive and infected mice. The results indicate that recovery from oropharyngeal candidiasis in this model is dependent on CD4 -T-cell augmentation of monocyte and neutrophil functions exerted by Th1-type cytokines such as IL-12 and IFN-gamma.
Keyword Candida
Phagocytes
Cytokines
Q-Index Code C1
Institutional Status UQ
Additional Notes Originally published as Farah, C.S. and Elahi, S. and Pang, G. and Gotjamanos, T. and Seymour, G.J. and Clancy, R.L. and Ashman, R.B. (2001) T Cells Augment Monocyte and Neutrophil Function in Host Resistance against Oropharyngeal Candidiasis. Infection and Immunity 69(10):6110-6118. Copyright 2001 The American Society for Microbiology. All rights reserved.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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Created: Fri, 11 Nov 2005, 10:00:00 EST by Robert Ashman on behalf of School of Dentistry