Neurological signs in inflammatory demyelination

Pender, Michael P. (1993) Neurological signs in inflammatory demyelination. Annals of Neurology, 33 5: 559-559. doi:10.1002/ana.410330524

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Author Pender, Michael P.
Title Neurological signs in inflammatory demyelination
Journal name Annals of Neurology   Check publisher's open access policy
ISSN 0364-5134
Publication date 1993-01-01
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1002/ana.410330524
Open Access Status File (Author Post-print)
Volume 33
Issue 5
Start page 559
End page 559
Total pages 1
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons
Language eng
Subject 321013 Neurology and Neuromuscular Diseases
Abstract Vass and colleagues recently reported that interferon-gamma potentiates antibody-mediated demyelination in the spinal cord in the rat. The rats developed prolongation of the latencies of somatosensory evoked potentials but no neurological signs. The authors stated that in this model there was more extended demyelination than is usually found in acute experimental allergic encephalomyelitis (EAE), and they concluded that their results contradicted the opinion that neurological dysfunction in rats with either actively induced or passively transferred EAE can be explained by demyelination alone. I wish to challenge their statement that there was more demyelination than usually present in acute EAE. In myelin basic protein-induced acute EAE (MBP-EAE) in the Lewis rat, there is substantial demyelination in the peripheral nervous system (PNS) randomly distributed along the lengths of the ventral and dorsal spinal roots. Significant demyelination is also present in the PNS in whole spinal cord-induced acute EAE in the rat. The lack of neurological signs in the model of Vass and colleagues is most likely explained by too few fibers in critical functional pathways undergoing demyelination simultaneously.
Keyword Acute experimental allergic encephalomyelitis
Experimental autoimmune encephalomyelitis
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Medicine Publications
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Created: Wed, 04 Jan 2006, 10:00:00 EST