Cox-2 inhibitors

Brooks, Peter M. (2000) Cox-2 inhibitors. Australian Prescriber, 23 2: 30-32.

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Author Brooks, Peter M.
Title Cox-2 inhibitors
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
1839-3942
Publication date 2000-02
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 23
Issue 2
Start page 30
End page 32
Total pages 3
Editor J. S. Dowden
F. G. Mackinnon
Place of publication Deakin, ACT, Australia
Publisher National Prescribing Service
Language eng
Subject 320503 Clinical Pharmacology and Therapeutics
Formatted abstract
There are two cyclo-oxygenase enzymes: COX-1 regulates physiological function in the gut and kidney, while COX-2 is induced in inflammation and repair. Selective COX-2 inhibitors are now available. In early clinical trials their efficacy in arthritis was equivalent to that of less selective non-steroidal anti-inflammatory drugs and they had a significantly lower incidence of gastrointestinal adverse effects. Larger and longer outcome studies are awaited to address issues such as a possible delaying effect of COX-2 inhibitors on ulcer healing and the potential for adverse cardiovascular effects.
Keyword Cyclo-oxygenase enzymes
Inhibitors
Arthritis
Ulcers
COX-1
COX-2
Anti-inflammatory drugs
Adverse effects
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Copied with permission of Australian Prescriber.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 27 Jan 2006, 10:00:00 EST by Di Thornthwaite on behalf of School of Medicine