Evidence for microsatellite instability in bilateral breast carcinomas

Imyanitov, EN, Togo, AV, Suspitsin, EN, Grigoriev, MY, Pozharisski, KM, Turkevich, EA, Hanson, KP, Hayward, NK, Chenevix-Trench, G, Theillet, C and Lavin, MF (2000) Evidence for microsatellite instability in bilateral breast carcinomas. Cancer Letters, 154 1: 9-17. doi:10.1016/S0304-3835(99)00444-9


Author Imyanitov, EN
Togo, AV
Suspitsin, EN
Grigoriev, MY
Pozharisski, KM
Turkevich, EA
Hanson, KP
Hayward, NK
Chenevix-Trench, G
Theillet, C
Lavin, MF
Title Evidence for microsatellite instability in bilateral breast carcinomas
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
Publication date 2000-06-01
Sub-type Article (original research)
DOI 10.1016/S0304-3835(99)00444-9
Volume 154
Issue 1
Start page 9
End page 17
Total pages 9
Place of publication Amsterdam
Publisher Elsevier Science Ireland
Collection year 2000
Language eng
Subject 321011 Medical Genetics
730108 Cancer and related disorders
730305 Diagnostic methods
C1
Abstract The molecular pathogenesis of various categories of breast cancer (BC) has been well described, but surprisingly few reports have appeared on analysis of somatic mutations in bilateral BC. We have performed a polymerase chain reaction (PCR)-driven investigation of chromosomal regions showing common loss of heterozygosity (LOH) in 23 cases (46 rumors) from patients diagnosed with bilateral BC, LOH was observed in 15/46 (33%) informative tumors for chromosome 1p, 5/32 (16%) for 5q, 12/44 (27%) for 11q, 15/40 (38%) for 13q and 4/24 (17%) for 17p. These values are within the range of interlaboratory variations reported fur unilateral BC, There was no strong evidence for concordance of LOH within the same patient for any of the chromosomal loci tested. Atypical for breast carcinomas, 7/46 (15%) turners accumulated a high frequency (ranging from 11 to 29%) of shortened dinucleotide CA repeats, implying microsatellite instability (MI). Further analysis with the highly informative BAT-26 marker allowed for the classification of two of these tumors as having a replication error positive (RER+/MSI-H) phenotype, whereas the remaining five carcinomas harbored so-called borderline MI. Thus an involvement of both RER+ and borderline MI appears to be a distinct feature of bilateral breast carcinomas compared to unilateral lesions. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Oncology
Bilateral Breast Cancer
Loss Of Heterozygosity
Microsatellite Instability
Colorectal-cancer
P53 Mutations
Gene
Heterozygosity
Susceptibility
Epidemiology
Leukemia
P73
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 20 Aug 2007, 01:10:59 EST