Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue

Jass, J. R., Constable, L., Sutherland, R., Winterford, CM, Walsh, M., Young, J. P. and Leggett, B. A. (2000) Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue. Histopathology, 36 2: 116-120. doi:10.1046/j.1365-2559.2000.00864.x


Author Jass, J. R.
Constable, L.
Sutherland, R.
Winterford, CM
Walsh, M.
Young, J. P.
Leggett, B. A.
Title Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue
Journal name Histopathology   Check publisher's open access policy
ISSN 0309-0167
1365-2559
Publication date 2000
Sub-type Article (original research)
DOI 10.1046/j.1365-2559.2000.00864.x
Volume 36
Issue 2
Start page 116
End page 120
Total pages 5
Place of publication Oxford, U.K.
Publisher Blackwell Science
Collection year 2000
Language eng
Subject C1
110316 Pathology (excl. Oral Pathology)
1112 Oncology and Carcinogenesis
Abstract Aims: An early adenocarcinoma of the ascending colon was confined to a mass of gut-associated lymphoid tissue (GALT). The first description of an adenocarcinoma of colon differentiating as dome epithelium is presented. Methods and results: A plaque-like carcinoma was identified opposite the ileocaecal valve in an asymptomatic 56-year-old man with a family history of colorectal cancer. Malignant epithelium was confined to a mass of GALT filling but limited to the submucosa, Characterization of the neoplasm was undertaken by means of mucin histochemistry, immunohistochemistry, electron microscopy and assessment of DNA microsatellite instability status. The malignant epithelium comprised well differentiated columnar cells with a microvillous brush border and expressing MUC1, but no goblet cells or expression of MUC2. The demonstration of focal clusters of intraepithelial B-lymphocytes supported the presence of functioning M-cells within the malignant neoplasm. The cancer was DNA microsatellite stable despite the finding of tumour infiltrating lymphocytes. Conclusions: There is evidence for the origin of colorectal neoplasia from dome epithelium in both experimental models and microreconstruction studies of early adenomas in nonpolypotic human colorectal mucose, It is suggested that the lymphocyte-rich subset of colorectal cancer that expresses MUC1 but not MUC2 may be differentiating as dome epithelium of gut-associated lymphoid tissue.
Keyword Cell Biology
Pathology
Carcinoma
Colon
Dome Epithelium
Lymphoid Tissue
M-cells
Colorectal-cancer
Peyers-patches
Expression
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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