Orthodontic tooth movement in the prednisolone-treated rat

Ong, Colin K. L., Walsh, Laurence J., Harbrow, Douglas, Taverne, Aart A. R. and Symons, Anne L. (2000) Orthodontic tooth movement in the prednisolone-treated rat. Angle Orthodontist, 70 2: 118-125.

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Author Ong, Colin K. L.
Walsh, Laurence J.
Harbrow, Douglas
Taverne, Aart A. R.
Symons, Anne L.
Title Orthodontic tooth movement in the prednisolone-treated rat
Journal name Angle Orthodontist   Check publisher's open access policy
ISSN 0003-3219
Publication date 2000-04
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 70
Issue 2
Start page 118
End page 125
Total pages 8
Place of publication Appleton, Wis. U.S.A.
Publisher Edward H. Angle Society of Orthodontia
Collection year 2000
Language eng
Subject C1
730112 Oro-dental and disorders
Abstract Adverse effects of corticosteroids on bone metabolism raise concerns as to whether steroid treatment may influence orthodontic movement. This study examined the effect of prednisolone on orthodontic movement using an established rat model. The corticosteroid treated group (N = 6) was administered prednisolone (1 mg/kg) daily, for a 12-day induction period; the control group (N = 6) received equivalent volumes of saline. On day 12, an orthodontic appliance was placed which exerted 30 g of mesial force to the maxillary first molar. Animals were sacrificed on day 24 and tooth movement was measured. Sagittal sections of the molars were stained with haematoxylin and eosin, and for tartrate-resistant acid phosphatase (TRAP) activity. While there were no significant differences in the magnitude of tooth movement between the 2 groups, steroid-treated rats displayed significantly less root resorption on the compression side and fewer TRAP-positive cells within the PDL space on the same side. This suggests steroid treatment suppressed elastic activity.
Keyword Dentistry, Oral Surgery & Medicine
Orthodontic Tooth Movement
Root Resorption
Resistant Acid-phosphatase
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
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Created: Sun, 19 Aug 2007, 15:08:53 EST