Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast

Baldock, Paul A., Thomas, Gethin P., Hodge, Jason M., Baker, Sara U. K., Dressel, Uwe, O'Loughlin, Peter D., Nicholson, Geoffrey C., Briffa, Kathy H., Eisman, John A. and Gardiner, Edith M. (2006) Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast. Journal of Bone and Mineral Research, 21 10: 1618-1626. doi:10.1359/JBMR.060714


Author Baldock, Paul A.
Thomas, Gethin P.
Hodge, Jason M.
Baker, Sara U. K.
Dressel, Uwe
O'Loughlin, Peter D.
Nicholson, Geoffrey C.
Briffa, Kathy H.
Eisman, John A.
Gardiner, Edith M.
Title Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast
Journal name Journal of Bone and Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 2006-10
Sub-type Article (original research)
DOI 10.1359/JBMR.060714
Volume 21
Issue 10
Start page 1618
End page 1626
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Collection year 2006
Language eng
Subject C1
321004 Endocrinology
730114 Skeletal system and disorders (incl. arthritis)
Abstract Vitamin D acts through the immature osteoblast to stimulate osteoclastogenesis. Transgenic elevation of VDR in mature osteoblasts was found to inhibit osteoclastogenesis associated with an altered OPG response. This inhibition was confined to cancellous bone. This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast.
Keyword Vitamin D
Osteoclastogenesis
Mature osteoblast
Osteoprotegerin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 10:59:45 EST