Physiological consequences of early-life insult

Schibler, Andreas (2006) Physiological consequences of early-life insult. Paediatric Respiratory Reviews, 7 2: 103-109. doi:10.1016/j.prrv.2006.03.006


Author Schibler, Andreas
Title Physiological consequences of early-life insult
Journal name Paediatric Respiratory Reviews   Check publisher's open access policy
ISSN 1526-0542
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.prrv.2006.03.006
Volume 7
Issue 2
Start page 103
End page 109
Total pages 7
Editor W. Lenney
Place of publication UK
Publisher W. B. Saunders Co. Ltd
Collection year 2006
Language eng
Subject C1
321019 Paediatrics
730204 Child health
Abstract The most commonly observed severe lung injuries in early life are the respiratory distress syndrome in premature infants and the acute respiratory distress syndrome in children. Both diseases are characterised by alveolar instability, fluid filled airspace and some degree of airway obstruction. In the acute phase, collapsed alveoli can be reopened with positive end-expiratory pressure and lung recruitment. New insight into the physiology of lung recruitment suggests that the shape of the pressure–volume curve is defined by the change in rate of alveolar opening and closing. Reduced lung volumes and severe ventilation maldistribution are found in the acute phase but may persist during childhood. Any severe lung injury in this early phase of life can cause significant structural and functional damage to the developing lung. Follow-up studies of children with chronic lung disease have shown that the functional abnormalities will improve but may still be present in later childhood.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 10:57:30 EST