The renal cortical fibroblast in renal tubulointerstitial fibrosis

Qi, Weier, Chen,Xinming, Poronnik, Philip and POLLOCK, Carol A. (2006) The renal cortical fibroblast in renal tubulointerstitial fibrosis. The International Journal of Biochemistry & Cell Biology, 38 1: 1-5. doi:10.1016/j.biocel.2005.09.005


Author Qi, Weier
Chen,Xinming
Poronnik, Philip
POLLOCK, Carol A.
Title The renal cortical fibroblast in renal tubulointerstitial fibrosis
Journal name The International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.biocel.2005.09.005
Volume 38
Issue 1
Start page 1
End page 5
Total pages 5
Editor Dr. Geoffrey J Laurent
Place of publication United Kingdom
Publisher Pergamon
Collection year 2006
Language eng
Subject C1
270104 Membrane Biology
320602 Cell Physiology
780105 Biological sciences
730115 Urogenital system and disorders
Abstract Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix (ECM) and maintenance of renal tissue architecture. They express a variety of cytokines, chemokines, growth factors and cell adhesion molecules, playing an active role in paracrine and autocrine interactions and regulating both fibrogenesis and the interstitial inflammatory response. They additionally have an endocrine function in the production of epoetin. Tubulointerstitial fibrosis, the common pathological consequence of renal injury, is characterized by the accumulation of extracellular matrix largely due to excessive production in parallel with reduced degradation, and activated fibroblasts characterized by a myofibroblastic phenotype. Fibroblasts in the kidney may derive from resident fibroblasts, from the circulating fibroblast population or from haemopoetic progenitor or stromal cells derived from the bone marrow. Cells exhibiting a myofibroblastic phenotype may derive from these sources and from tubular cells undergoing epithelial to mesenchymal transformation in response to renal injury. The number of interstitial myofibroblasts correlates closely with tubulointerstitial fibrosis and progressive renal failure. Hence inhibiting myofibroblast formation may be an effective strategy in attenuating the development of renal failure in kidney disease of diverse etiology. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Cell Biology
Cortical Fibroblasts
Myofibroblasts
Extracellular Matrix Accumulation
Tubulointerstitial Fibrosis
Tissue Growth-factor
Proximal Tubule Cells
Interstitial Fibrosis
Tgf-beta
Fibrogenesis
Activation
Mechanisms
Kidney
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 10:55:34 EST