Foaming properties of a peptide designed to form stimuli-responsive interfacial films

Malcolm, Andrew S., Dexter, Annette. F. and Middelberg, Anton P. J. (2006) Foaming properties of a peptide designed to form stimuli-responsive interfacial films. Soft Matter, 2 12: 1057-1066. doi:10.1039/b609960b

Author Malcolm, Andrew S.
Dexter, Annette. F.
Middelberg, Anton P. J.
Title Foaming properties of a peptide designed to form stimuli-responsive interfacial films
Journal name Soft Matter   Check publisher's open access policy
ISSN 1744-683X
Publication date 2006
Sub-type Article (original research)
DOI 10.1039/b609960b
Open Access Status Not Open Access
Volume 2
Issue 12
Start page 1057
End page 1066
Total pages 10
Editor Ms. Janet L Dean
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2006
Language eng
Abstract We have designed an amphipathic peptide, AM1, that can self-assemble at the air-water interface to form an interfacial ensemble capable of switching between a mechanically strong cohesive film state and a mobile detergent state in response to changes in the solution conditions. The mechanical properties of the AM1 ensemble in the cohesive film state are qualitatively equivalent to the protein beta-LG, while in the mobile detergent state they are equivalent to the low molecular weight surfactant, SDS. In this work the foaming properties of AM1 are compared to those of beta-LG and SDS at the same weight concentration and it is found that AM1 adsorbs rapidly to the interface, initially forming a dense foam like that formed by SDS and superior to beta-LG. In addition, under solution conditions where interfacially adsorbed AM1 forms a cohesive film state the foam stability is high, comparable to beta-LG. However when the interfacially adsorbed AM1 forms a foam under detergent-state conditions, the foam stability is poor. We have achieved control of foam stability through the design of a peptide that exhibits stimuli-responsive changes in the extent of intermolecular interactions between peptide molecules adsorbed at the air water interface. These results illustrate the exciting potential of peptide surfactants to form a new class of stimuli-responsive foaming agents.
Keyword Air-water Interfaces
Adsorbed Protein Layers
Rheological Properties
Surface Forces
Aqueous Films
Materials Science, Multidisciplinary
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 10:37:27 EST