Effect of the BDNF V166M polymorphism on working memory in healthy adolescents

Hansell, N. K., James, M. R., Duffy, D. L., Birley, A. J., Luciano, M., Geffen, G. M., Wright, M. J., Montgomery, G. W. and Martin, N. G. (2007) Effect of the BDNF V166M polymorphism on working memory in healthy adolescents. Genes, Brain and Behavior, 6 3: 260-268. doi:10.1111/j.1601-183X.2006.00254.x


Author Hansell, N. K.
James, M. R.
Duffy, D. L.
Birley, A. J.
Luciano, M.
Geffen, G. M.
Wright, M. J.
Montgomery, G. W.
Martin, N. G.
Title Effect of the BDNF V166M polymorphism on working memory in healthy adolescents
Journal name Genes, Brain and Behavior   Check publisher's open access policy
ISSN 1601-1848
1601-183X
Publication date 2007-04
Sub-type Article (original research)
DOI 10.1111/j.1601-183X.2006.00254.x
Volume 6
Issue 3
Start page 260
End page 268
Total pages 9
Place of publication Oxford, U.K.
Publisher Wiley-Blackwell
Collection year 2006
Language eng
Subject C1
389999 Other Behavioural and Cognitive Sciences
730299 Public health not elsewhere classified
0604 Genetics
1109 Neurosciences
1702 Cognitive Sciences
Formatted abstract
Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (α = 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.
Keyword Delayed-response
Event-related potentials
Genes
QTDT
Twins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 10:33:23 EST