Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting

Molenaar, Peter, Chen, Lu and Parsonage, William A. (2006) Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting. British Journal of Pharmacology, 147 6: 583-586. doi:10.1038/sj.bjp.0706670


Author Molenaar, Peter
Chen, Lu
Parsonage, William A.
Title Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting
Journal name British Journal of Pharmacology   Check publisher's open access policy
ISSN 0007-1188
Publication date 2006
Sub-type Editorial
DOI 10.1038/sj.bjp.0706670
Volume 147
Issue 6
Start page 583
End page 586
Total pages 4
Editor H. Rang
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2006
Language eng
Subject C1
320502 Basic Pharmacology
730106 Cardiovascular system and diseases
CX
Abstract There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients.
Keyword Pharmacology & Pharmacy
Skeletal Muscle
Muscle Wasting
Human Heart
Arrhythmias
Beta(2)-adrenoceptor
Formoterol
Salmeterol
Chronic Heart-failure
Rat Skeletal-muscles
Ventricular Myocardium
Cardiovascular Safety
Troponin-i
Receptor
Hypertrophy
Salbutamol
Relaxation
Q-Index Code C1

Document type: Journal Article
Sub-type: Editorial
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 10:33:12 EST