Does high intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes

Daly, R. M., Dunstan, D. W., Owen, N. G., Jolley, D., Shaw, J. E. and Zimmet, P. Z. (2005) Does high intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes. Osteoporosis International, 16 12: 1703-1712. doi:10.1007/s00198-005-1906-4


Author Daly, R. M.
Dunstan, D. W.
Owen, N. G.
Jolley, D.
Shaw, J. E.
Zimmet, P. Z.
Title Does high intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes
Journal name Osteoporosis International   Check publisher's open access policy
ISSN 0937-941X
1433-2965
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1007/s00198-005-1906-4
Volume 16
Issue 12
Start page 1703
End page 1712
Total pages 10
Place of publication Guildford, UK
Publisher Springer-Verlag London
Collection year 2006
Language eng
Subject C1
321004 Endocrinology
730203 Health related to ageing
1103 Clinical Sciences
Abstract The aim was to investigate whether the addition of supervised high intensity progressive resistance training to a moderate weight loss program (RT+WLoss) could maintain bone mineral density (BMD) and lean mass compared to moderate weight loss (WLoss) alone in older overweight adults with type 2 diabetes. We also investigated whether any benefits derived from a supervised RT program could be sustained through an additional home-based program. This was a 12-month trial in which 36 sedentary, overweight adults aged 60 to 80 years with type 2 diabetes were randomized to either a supervised gymnasium-based RT+WLoss or WLoss program for 6 months (phase 1). Thereafter, all participants completed an additional 6-month home-based training without further dietary modification (phase 2). Total body and regional BMD and bone mineral content (BMC), fat mass (FM) and lean mass (LM) were assessed by DXA every 6 months. Diet, muscle strength (1-RM) and serum total testosterone, estradiol, SHBG, insulin and IGF-1 were measured every 3 months. No between group differences were detected for changes in any of the hormonal parameters at any measurement point. In phase 1, after 6 months of gymnasium-based training, weight and FM decreased similarly in both groups (P < 0.01), but LM tended to increase in the RT+WLoss (n=16) relative to the WLoss (n = 13) group [net difference (95% CI), 1.8% (0.2, 3.5), P < 0.05]. Total body BMD and BMC remained unchanged in the RT+WLoss group, but decreased by 0.9 and 1.5%, respectively, in the WLoss group (interaction, P < 0.05). Similar, though non-significant, changes were detected at the femoral neck and lumbar spine (L2-L4). In phase 2, after a further 6 months of home-based training, weight and FM increased significantly in both the RT+WLoss (n = 14) and WLoss (n = 12) group, but there were no significant changes in LM or total body or regional BMD or BMC in either group from 6 to 12 months. These results indicate that in older, overweight adults with type 2 diabetes, dietary modification should be combined with progressive resistance training to optimize the effects on body composition without having a negative effect on bone health.
Keyword Endocrinology & Metabolism
bone mineral density
resistance training
type 2 diabetes
weight loss
Lean Tissue Mass
Postmenopausal Women
Mineral Density
Glycemic Control
Hip Fracture
Risk-factors
White Women
Young-women
Obese Women
Exercise
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 10:20:59 EST