Evidence of altered prefrontal-thalamic circuitry in schizophrenia: An optimised diffusion MRI study

Rose, Stephen E., Chalk, Jonathan B., Janke, Andrew L., Strudwick, Mark W., Windus, Louisa C., Hannah, Dominique E., McGrath, John J., Pantelis, Christos, Wood, Stephen J. and Mowry, Bryan J. (2006) Evidence of altered prefrontal-thalamic circuitry in schizophrenia: An optimised diffusion MRI study. NeuroImage, 32 1: 16-22.


Author Rose, Stephen E.
Chalk, Jonathan B.
Janke, Andrew L.
Strudwick, Mark W.
Windus, Louisa C.
Hannah, Dominique E.
McGrath, John J.
Pantelis, Christos
Wood, Stephen J.
Mowry, Bryan J.
Title Evidence of altered prefrontal-thalamic circuitry in schizophrenia: An optimised diffusion MRI study
Journal name NeuroImage  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2006-08-01
Sub-type Article
DOI 10.1016/j.neuroimage.2006.03.003
Volume number 32
Issue number 1
ISSN 1053-8119; 1095-9572
Start page 16
End page 22
Total pages 7
Editor J. C. Mazziotta
R. S. J. Frackowiak
K. J. Friston
Place of publication San Diego
Publisher Academic Press Inc Elsevier Science
Collection year 2006
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract MRI diffusion tensor imaging (DTI), optimized for measuring the trace of the diffusion tensor, was used to investigate microstructural changes in the brains of 12 individuals with schizophrenia compared with 12 matched control subjects. To control for the effects of anatomic variation between subject groups, all participants' diffusion images were non-linearly registered to standard anatomical space. Significant statistical differences in mean diffusivity (MD) measures between the two groups were determined on a pixel-by-pixel basis, using Gaussian random field theory. We found significantly elevated MD measures within temporal, parietal and prefrontal cortical regions in the schizophrenia group (P > 0.001), especially within the medial frontal gyrus and anterior cingulate. The dorsal medial and anterior nucleus of the thalamus, including the caudate, also exhibited significantly increased MD in the schizophrenia group (P > 0.001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal-thalamic circuitry in schizophrenia. (c) 2006 Elsevier Inc. All rights reserved.
Keyword Neurosciences
Neuroimaging
Radiology, Nuclear Medicine & Medical Imaging
Schizophrenia
Diffusion Mri
Thalamus
Anterior Cingulate
Anterior Cingulate Cortex
Voxel-based Morphometry
Statistical-analysis
Controlled Family
Neuronal Density
Twins Discordant
Volume
Abnormalities
Brain
Mediodorsal
Q-Index Code C1

 
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