Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task

Hansell, N. K., Medland, S. E., Ferreira, A. R., Geffen, G. M., Zhu, G., Montgomery, G. W., Duffy, D. L. and Martin, N. G. (2006) Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task. Behavior Genetics, 36 1: 29-44. doi:10.1007/s10519-005-9002-2


Author Hansell, N. K.
Medland, S. E.
Ferreira, A. R.
Geffen, G. M.
Zhu, G.
Montgomery, G. W.
Duffy, D. L.
Martin, N. G.
Title Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2006
Sub-type Article (original research)
DOI 10.1007/s10519-005-9002-2
Volume 36
Issue 1
Start page 29
End page 44
Total pages 16
Place of publication New York, United States
Publisher Springer
Collection year 2006
Language eng
Subject C1
389999 Other Behavioural and Cognitive Sciences
730299 Public health not elsewhere classified
Abstract Working memory is an essential component of wide-ranging cognitive functions. It is a complex genetic trait probably influenced by numerous genes that individually have only a small influence. These genes may have an amplified influence on phenotypes closer to the gene action. In this study, event-related potential (ERP) phenotypes recorded during a working-memory task were collected from 656 adolescents from 299 families for whom genotypes were available. Univariate linkage analyses using the MERLIN variance-components method were conducted on slow wave phenotypes recorded at multiple sites while participants were required to remember the location of a target. Suggestive linkage (LOD > 2.2) was found on chromosomes 4, 5, 6, 10, 17, and 20. After correcting for multiple testing, suggestive linkage remained on chromosome 10. Empirical thresholds were computed for the most promising phenotypes. Those on chromosome 10 remained suggestive. A number of genes reported to regulate neural differentiation and function (i.e. NRP1, ANK3, and CHAT) were found under these linkage peaks and may influence the levels of neural activity occurring in individuals participating in a spatial working-memory task.
Keyword Behavioral sciences
Genetics and heredity
Psychology, multidisciplinary
Chromosome 10
Merlin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 10:11:15 EST