Indocyanine green elimination: A comparison of the limon and serial blood sampling methods

Purcell, Roslyn, Kruger, Peter and Jones, Mmark (2006) Indocyanine green elimination: A comparison of the limon and serial blood sampling methods. Anz Journal of Surgery, 76 1-2: 75-77. doi:10.1111/j.1445-2197.2006.03643.x

Author Purcell, Roslyn
Kruger, Peter
Jones, Mmark
Title Indocyanine green elimination: A comparison of the limon and serial blood sampling methods
Journal name Anz Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.2006.03643.x
Volume 76
Issue 1-2
Start page 75
End page 77
Total pages 3
Editor R. J. S. Thomas
Place of publication Richmond, VIC, Australia
Publisher Blackwell Publishing Asia
Collection year 2006
Language eng
Subject 321006 Gastroenterology and Hepatology
730113 Digestive system and disorders
Formatted abstract
Indocyanine green (ICG) elimination is a test widely used to evaluate hepatic functional reserve in patients being assessed for hepatic resection. This study compares a non-invasive liver function monitoring system, the LiMON (Pulsion Medical Systems, Munich, Germany), with serial blood sampling methods.

ICG elimination was measured by the LiMON, spectrophotometry and high-performance liquid chromatography (HPLC) in 20 patients with hepatocellular carcinoma and cirrhosis as part of their preoperative work-up.

The ICG 15-min retention rates obtained by spectrophotometry and HPLC correlated well (correlation coefficient = 0.91), and there was good agreement between the tests (mean bias = 2.93, 95% confidence interval (CI) = 1.59-4.28). There was a reasonably strong correlation between results obtained with the LiMON and spectrophotometry (correlation coefficient = 0.81), and again there was good agreement between the tests (mean bias = 2.71, 95% CI = 0.19-5.22). On average, 15-min retention rates measured by the LiMON were 2.71 lower than those measured with spectrophotometry.


In patients being assessed for suitability of hepatic resection, the LiMON provides results similar to those obtained by serial blood sampling methods. This is important as techniques of carrying out ICG elimination vary widely between institutions and results are frequently incorporated into scoring systems that are used to determine surgical decisions.
Keyword Surgery
Hepatic Resection
Hepatocellular Carcinoma
Indocyanine Green
Liver Function Test
Pulse Spectrophotometry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 10:08:55 EST