Beta-lactam allergy in adults with cystic fibrosis

Burrows, Judith A., Nissen, Lisa M., Kirkpatrick, Carl M. J. and Bell, Scott. C. (2007) Beta-lactam allergy in adults with cystic fibrosis. Journal of Cystic Fibrosis, 6 4: 297-303. doi:10.1016/j.jcf.2006.11.001

Author Burrows, Judith A.
Nissen, Lisa M.
Kirkpatrick, Carl M. J.
Bell, Scott. C.
Title Beta-lactam allergy in adults with cystic fibrosis
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
ISSN 1569-1993
Publication date 2007-07
Sub-type Article (original research)
DOI 10.1016/j.jcf.2006.11.001
Volume 6
Issue 4
Start page 297
End page 303
Total pages 7
Editor H. G. M. Heijerman
Place of publication Amsterdam
Publisher Elsevier Science Bv
Collection year 2006
Language eng
Subject C1
320200 Immunology
730102 Immune system and allergy
321027 Respiratory Diseases
730110 Respiratory system and diseases (incl. asthma)
Abstract Background: Allergic reactions to one or more beta-lactam antibiotic can pose a management problem in patients with cystic fibrosis (CF), and may limit antibiotic choice. Method: The aim of this study was to assess the prevalence of allergy to anti-pseudomonal beta-lactam antibiotics in an adult CF centre and to assess variables, which may contribute to the development of allergic reactions. A questionnaire-based interview and a review of medical records were performed. Results: Of the 150 patients, 54 (36%) had allergic reactions to one or more beta-lactam antibiotics and 20 (19%) had allergic reactions to multiple beta-lactam antibiotics. The proportion of patients allergic to specific beta-lactam antibiotics varied from 10% to 26%. Rates of reactions were highest for penicillins and cephalosporins, intermediate for carbepenems and lowest for aztreonam. Of all reactions, 40% occurred within 24 h of the commencement of an individual antibiotic course. Patients with one or more beta-lactam allergic reactions had received greater cumulative exposure (p < 0.0001), were older (p=0.016) and had lower lung function (p=0.037) than patients without a history of beta-lactam allergy. Cystic Fibrosis transmembrane regulator (CFTR) status, gender, peripheral blood eosinophil count and total IgE concentrations were not different in patients with allergic reactions. Conclusions: This study demonstrates that the prevalence of allergic reactions to beta-lactam antibiotics is high in adults with CF. Increasing age; cumulative exposure and decreasing FEV1 were associated with the development of allergy. (C) 2006 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Keyword Respiratory System
cystic fibrosis
Hypersensitivity Reactions
Antibiotic Hypersensitivity
Penicillin Allergy
Adverse Reactions
Q-Index Code C1
Additional Notes Include in the 2008 Bibliographic Data Collection for 2007 publications according to the old definition of 'publication year': “The year of publication is normally the LATEST of the year indicated as published, printed or the year of copyright”.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 10:05:39 EST