Genes and gene expression in the brains of human alcoholics

Dodd, Peter R., Buckley, S. Tracey, Eckert, Allison L., Foley, Philomena F. and Innes, David J. (2006) Genes and gene expression in the brains of human alcoholics. Annals of the New York Academy of Sciences, 1074 104-115. doi:10.1196/annals.1369.010

Author Dodd, Peter R.
Buckley, S. Tracey
Eckert, Allison L.
Foley, Philomena F.
Innes, David J.
Title Genes and gene expression in the brains of human alcoholics
Journal name Annals of the New York Academy of Sciences   Check publisher's open access policy
ISSN 0077-8923
ISBN 1-57331-629-6
Publication date 2006-08
Year available 2006
Sub-type Article (original research)
DOI 10.1196/annals.1369.010
Volume 1074
Start page 104
End page 115
Total pages 12
Editor Douglas Braaten
Place of publication New York
Publisher New York Academy of Sciences
Collection year 2006
Language eng
Subject C1
270201 Gene Expression
270203 Population and Ecological Genetics
730205 Substance abuse
1109 Neurosciences
1101 Medical Biochemistry and Metabolomics
Abstract Chronic alcohol misuse by human subjects leads to neuronal loss in regions such as the superior frontal cortex (SFC). Propensity to alcoholism is associated with several genes. γ-Aminobutyric acid (GABA)A receptor expression differs between alcoholics and controls, whereas glutamate receptor differences are muted. We determined whether genotype differentiated the regional presentation of GABAA and glutamate-NMDA (N-methyl-d-aspartate) receptors in SFC. Autopsy tissue was obtained from alcoholics without comorbid disease, alcoholics with liver cirrhosis, and matched controls. ADH1C, DRD2B, EAAT2, and APOE genotypes modulated GABAA-β subunit protein expression in SFC toward a less-effective form of the receptor. Most genotypes did not divide alcoholics and controls on glutamate-NMDA receptor pharmacology, although gender and cirrhosis did. Genotype may affect amino acid transmission locally to influence neuronal vulnerability.
Keyword pathogenesis
substance misuse and dependence
brain damage
cerebral cortex
Q-Index Code C1
Additional Notes Volume title: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines

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Created: Wed, 15 Aug 2007, 10:04:27 EST