Change in lean body mass Is a major determinant of change in areal bone mineral density of the proximal femur: A 12-year observational study

Liu-Ambrose, T., Kravetsky, L., Bailey, D., Sherar, L., Mundt, C., Baxter-Jones, A., Khan, K. M. and McKay, H. A. (2006) Change in lean body mass Is a major determinant of change in areal bone mineral density of the proximal femur: A 12-year observational study. Calcified Tissue International, 79 3: 145-151. doi:10.1007/s00223-006-0098-z


Author Liu-Ambrose, T.
Kravetsky, L.
Bailey, D.
Sherar, L.
Mundt, C.
Baxter-Jones, A.
Khan, K. M.
McKay, H. A.
Title Change in lean body mass Is a major determinant of change in areal bone mineral density of the proximal femur: A 12-year observational study
Journal name Calcified Tissue International   Check publisher's open access policy
ISSN 0171-967X
0008-0594
Publication date 2006-09
Sub-type Article (original research)
DOI 10.1007/s00223-006-0098-z
Volume 79
Issue 3
Start page 145
End page 151
Total pages 7
Place of publication New York, United States
Publisher Springer
Language eng
Subject C1
321017 Orthopaedics
321019 Paediatrics
730114 Skeletal system and disorders (incl. arthritis)
730204 Child health
1103 Clinical Sciences
Abstract Our objective was to assess the contribution of lean body mass (LBM) and fat body mass (FBM) to areal bone mineral density (aBMD) in women during the years surrounding menopause. We used a 12-year observational design. Participants included 75 Caucasian women who were premenopausal, 53 of whom were available for follow-up. There were two measurement periods: baseline and 12-year follow-up. At both measurement periods, bone mineral content and aBMD of the proximal femur, posterior-anterior lumbar spine, and total body was assessed using dual-energy X-ray absorptiometry (DXA). LBM and FBM were derived from the total-body scans. General health, including current menopausal status, hormone replace therapy use, medication use, and physical activity, was assessed by questionnaires. At the end of the study, 44% of the women were postmenopausal. After controlling for baseline aBMD, current menopausal status, and current hormone replacement therapy, we found that change in LBM was independently associated with change in aBMD of the proximal femur (P = 0.001). The cross-sectional analyses also indicated that LBM was a significant determinant of aBMD of all three DXA-scanned sites at both baseline and follow-up. These novel longitudinal data highlight the important contribution of LBM to the maintenance of proximal femur bone mass at a key time in women's life span, the years surrounding menopause.
Keyword Body composition
Areal bone mineral density
Dual-energy X-ray
Absorptiometry
Longitudinal
Women
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 09:57:15 EST