A retrospective audit of hospital records evaluating change in respiratory function during hospitalization for pulmonary exacerbation in a paediatric population with cystic fibrosis

Wilson, Christine, Macdonald, Julie, Watter, Pauline and O'Rourke, Peter (2006) A retrospective audit of hospital records evaluating change in respiratory function during hospitalization for pulmonary exacerbation in a paediatric population with cystic fibrosis. Physiotherapy, 92 4: 219-224.


Author Wilson, Christine
Macdonald, Julie
Watter, Pauline
O'Rourke, Peter
Title A retrospective audit of hospital records evaluating change in respiratory function during hospitalization for pulmonary exacerbation in a paediatric population with cystic fibrosis
Journal name Physiotherapy   Check publisher's open access policy
ISSN 0031-9406
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1016/j.physio.2006.05.009
Volume 92
Issue 4
Start page 219
End page 224
Total pages 6
Editor M. Harms
Place of publication Kidlington, Oxford, U.K.
Publisher Elsevier
Collection year 2006
Language eng
Subject C1
321024 Rehabilitation and Therapy - Occupational and Physical
730303 Occupational, speech and physiotherapy
Formatted abstract Objectives
To determine the rate of change in lung function during hospitalisation in young people with cystic fibrosis using forced expiratory volume in 1 second (FEV1) and sputum expectorated at admission.

Design

Retrospective audit of hospital records from 1998 and 2000.

Setting

Tertiary paediatric hospital.

Participants

One hundred and twenty-six young people admitted during an acute pulmonary exacerbation.

Outcome measures

Sputum weight at admission, FEV1, forced vital capacity (FVC) and forced expiratory flow rate. Participants were grouped into bands according to FEV1 severity and expectorated sputum weight at admission.

Results

Significant differences were found in the rate of change of FEV1 and FVC across FEV1 bands and sputum groups during hospitalisation. Those in the moderate FEV1 band demonstrated a greater rate of change in FEV1 [mean 0.95, 95% confidence intervals (CI) 0.75–1.18] than those in the normal FEV1 band (mean 0.11, 95% CI −0.42 to 0.64). Those in the moderate and severe FEV1 bands had a greater rate of change in FVC (means 0.88 and 0.86, 95% CI 0.63 to 1.13 and 0.56 to 1.16, respectively) than those in the normal FEV1 band (mean −0.07, 95% CI −0.63 to 0.48). Those producing more than 10 g of sputum had a greater rate of improvement in FEV1 (mean 1.03, 95% CI 0.69 to 1.37) than those producing 1 to 10 g of sputum (mean 0.47, 95% CI 0.27 to 0.66). Those producing more than 10 g of sputum had a greater rate of improvement in FVC (mean 1.10, 95% CI 0.79 to 1.41) than those producing 1 to 10 g of sputum (mean 0.51, 95% CI 0.29 to 0.72).

Conclusions

In this cohort, improved rates of change in FEV1 and FVC during hospitalisation were related to FEV1 severity and sputum production at admission.
Keyword Cystic fibrosis
Young people
Respiratory function tests
Sputum
Q-Index Code C1

 
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