TRALI in 2 cases of leukemia

Fung, Yoke Lin and Williams, Bronwyn Anne (2006) TRALI in 2 cases of leukemia. Journal of Pediatric Hematology / Oncology, 28 6: 391-394. doi:10.1097/00043426-200606000-00014


Author Fung, Yoke Lin
Williams, Bronwyn Anne
Title TRALI in 2 cases of leukemia
Journal name Journal of Pediatric Hematology / Oncology   Check publisher's open access policy
ISSN 1077-4114
1536-3678
Publication date 2006-06
Sub-type Article (original research)
DOI 10.1097/00043426-200606000-00014
Volume 28
Issue 6
Start page 391
End page 394
Total pages 4
Editor B. A. Kamen
Place of publication Philadelphia, U.S.A.
Publisher Lippincott Williams & Wilkins
Collection year 2006
Language eng
Subject C1
321008 Haematology
321019 Paediatrics
730110 Respiratory system and diseases (incl. asthma)
730102 Immune system and allergy
Abstract We describe transfusion-related acute lung injury (TRALI) in 2 acute leukemia cases to increase awareness of this under reported serious transfusion complication syndrome in multitransfused patients. There are a number of reports in multitransfused patients with nonmalignant disorders. However, reports of pediatric oncology patients are few, suggesting a lack of recognition or misdiagnosis of the syndrome. A disproportionately high number of fatalities in children is recorded in the literature. This highlights the need for increased awareness and appropriate treatment of this serious complication of transfusion. Although TRALI is initially a clinical diagnosis, the laboratory investigation is vital as it contributes to defining the pathogenesis of the syndrome and importantly facilitates the effective management of implicated donations and donors. An investigational strategy for suspected cases is presented and the results are discussed in the context of current proposed mechanisms for TRALI. As each transfused blood product is associated with a potential risk of TRALI, more frequent reports in patients receiving large volume or recurrent transfusion would be expected.
Keyword Oncology
Hematology
Pediatrics
Trali
Leukemia
Transfusion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 09:53:27 EST