Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint

Burne, Thomas H.J., OLoan, Jonathon, McGrath, John J. and Eyles, Darryl W. (2006) Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint. Behavioural Brain Research, 174 1: 119-124. doi:10.1016/j.bbr.2006.07.015


Author Burne, Thomas H.J.
OLoan, Jonathon
McGrath, John J.
Eyles, Darryl W.
Title Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
1872-7549
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.bbr.2006.07.015
Volume 174
Issue 1
Start page 119
End page 124
Total pages 6
Editor J. P. Hudson
T. E. Robinson
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2006
Language eng
Subject 780108 Behavioural and cognitive sciences
730211 Mental health
Abstract Transient prenatal vitamin D deficiency produces hyperlocomotion in the adult rat. The aim of this study was to examine the effects of acute restraint on the behaviour of DVD and control rats in the open field. Rats were conceived and born to developmentally vitamin D (DVD) deficient or replete (control) dams and, at 8 weeks of age, were monitored for 30 min in an open field using automated video tracking software. Half of the rats were restrained within a towel for 5 min immediately before the open field test. The remainder received minimal handling prior to the open field test. Repeating previous findings, DVD deficient animals had enhanced locomotion during the first 10 min of the open field test compared to control rats. By contrast, there were no differences in locomotor activity after acute restraint stress. The time rats spent in the corners and side of the open field was affected by prenatal diet. DVD rats spent less time in the corners and more time in the side than control rats across the whole 30 min test. This difference was not seen in rats with acute restraint stress. The time spent in the centre was not altered by prenatal diet or acute restraint. Thus, transient prenatal vitamin D deficiency induces a transient spontaneous hyperlocomotion in adulthood that is modulated by acute restraint stress. (c) 2006 Elsevier B.V. All rights reserved.
Keyword Behavioral Sciences
Neurosciences
Locomotor Activity
Development
Sprague-dawley Rats
Restraint
Vitamin D
Behaviour
Brain-development
Adult Rats
Schizophrenia
Behavior
Alters
Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Wed, 15 Aug 2007, 09:52:31 EST