Use of latent profile analysis to identify eating disorder phenotypes in an adult Australian twin cohort

Wade, Tracey D., Crosby, Ross D. and Martin, Nicholas G. (2006) Use of latent profile analysis to identify eating disorder phenotypes in an adult Australian twin cohort. Archives of General Psychiatry, 63 12: 1377-1384. doi:10.1001/archpsyc.63.12.1377

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Author Wade, Tracey D.
Crosby, Ross D.
Martin, Nicholas G.
Title Use of latent profile analysis to identify eating disorder phenotypes in an adult Australian twin cohort
Journal name Archives of General Psychiatry   Check publisher's open access policy
ISSN 0003-990X
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1001/archpsyc.63.12.1377
Volume 63
Issue 12
Start page 1377
End page 1384
Total pages 8
Editor J. T. Coyle
C. D. DeAngelis
Place of publication Chicago, IL, United States
Publisher American Medical Association
Collection year 2006
Language eng
Abstract Context: The relationships among the different eating disorders that exist in the community are poorly understood, especially for residual disorders in which bingeing or purging occurs in the absence of other behaviors. Objective: To examine a community sample for the number of mutually exclusive weight and eating profiles. Design: Data regarding lifetime eating disorder symptoms and weight range were submitted to a latent profile analysis. Profiles were compared regarding personality, current eating and weight, retrospectively reported life events, and lifetime depressive psychopathology. Setting: Longitudinal study among female twins from the Australian Twin Registry in whom eating was assessed by a telephone interview. Participants: A community sample of 1002 twins (individuals) who had participated in earlier waves of data collection. Main Outcome Measures: Number and clinical character of latent profiles. Results: The best fit was a 5-profile solution with women who were (1) of normal weight with few lifetime eating disorders (4.3%), (2) overweight (10.6% had a lifetime eating disorder), (3) underweight and generally had no eating disorders except for 5.3% who had restricting anorexia nervosa, (4) of low to normal weight (89.0% had a lifetime eating disorder), and (5) obese (37.0% had a lifetime eating disorder). Each profile contained more than 1 type of lifetime eating disorder except for the third profile. Women in the first and third profiles had the best functioning, with women in the fourth and fifth profiles having similarly poorer functioning. The women in the fourth group had a symptom profile distinctive from the other 4 groups in terms of severity; they were also more likely to have had lifetime major depression and suicidality. Conclusion: Lifetime weight ranges and the severity of eating disorder symptoms affected clustering more than the type of eating disorder symptom.
Keyword Psychiatry
Major Depression
Community Sample
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 15 Aug 2007, 09:51:01 EST